L8000

L-Leucine

≥98% (HPLC), suitable for ligand binding assays

• Synonym(s): (S)-2-Amino-4-methylpentanoic acid
• Linear Formula: (CH₃)₂CHCH₂CH(NH₂)CO₂H
• CAS Number: 61-90-5
• Molecular Weight: 131.17
• NACRES: NA.26
• PubChem Substance ID: 24896488
• eCl@ss: 32160406
• UNSPSC Code: 12352209
• EC Number: 200-522-0
• MDL number: MFCD00002617
• Beilstein/REAXYS Number: 1721722

Properties

• Product Name: L-Leucine, reagent grade, ≥98% (HPLC)
• grade: reagent grade
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• technique(s): ligand binding assay: suitable
• impurities: isoleucine and methionine, essentially free
• color: white to off-white
• mp: >300 °C (lit.)
• application(s): peptide synthesis
• SMILES string: CC(C)C[C@H](N)C(O)=O
• InChI: 1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
• InChI key: ROHFNLRQFUQHCH-YFKPBYRVSA-N

Description

Application

L-Leucine has been used as an agonist of mechanistic target of rapamycin (mTOR) to determine whether AMPK/mTOR pathway is involved in berberine-mediated autophagy in J774A.1 cells. It has also been used for the selection of transformed cells.

Biochem/physiol Actions

Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to the formation of ketone bodies.

Safety Information

• Storage Class: 11 - Combustible Solids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)