L5139

Lycorine hydrochloride

powder, ≥98% (TLC)

• Synonym(s): Licorin hydrochloride, Lychorine chloride, Lycorine HCl
• Empirical Formula (Hill Notation): C₁₆H₁₇NO₄ · HCl
• CAS Number: 2188-68-3
• Molecular Weight: 323.77
• UNSPSC Code: 12352202
• PubChem Substance ID: 24896395
• NACRES: NA.77
• MDL number: MFCD00243111

Properties

• Product Name: Lycorine hydrochloride, ≥98% (TLC), powder
• Quality Segment: 100
• assay: ≥98% (TLC)
• form: powder
• mp: 210-212 °C
• solubility: ethanol: 10 mg/mL, clear, colorless to very faintly yellow
• storage temp.: 2-8°C
• SMILES string: Cl.O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4[C@H]([C@@H]1O)[C@@H]23
• InChI: 1S/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1
• InChI key: VUVNTYCHKZBOMV-NVJKKXITSA-N

Description

Biochem/physiol Actions

A selective inhibitor of peptidyl transferase center (PTC).

A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.

Disclaimer

Protect from light.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Codes: H301
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges