I5784

Ibandronate sodium salt

≥97% (NMR), solid

• Synonym(s): (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid sodium, Bondronat
• Empirical Formula (Hill Notation): C₉H₂₂NNaO₇P₂
• CAS Number: 138844-81-2
• Molecular Weight: 341.21
• NACRES: NA.77
• PubChem Substance ID: 329815388
• UNSPSC Code: 41106300
• MDL number: MFCD07197214
• Assay: ≥97% (NMR)
• Form: solid
• Storage condition: protect from light

Properties

• assay: ≥97% (NMR)
• form: solid
• storage condition: protect from light
• color: white
• solubility: H₂O: >10 mg/mL
• originator: Roche
• storage temp.: 2-8°C
• SMILES string: [Na+].CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)([O-])=O
• InChI: 1S/C9H23NO7P2.Na/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);/q;+1/p-1
• InChI key: LXLBEOAZMZAZND-UHFFFAOYSA-M
• Gene Information: human ... FDPS(2224)

Description

Application

Ibandronate sodium salt has been used to study its effect on the proliferation and ultrastructure of Leishmania and Giardia by the generation of concentration curves. It has also been used to elucidate the route by which nitrogen-containing bisphosphonates (N-BPs) enter the cytosol and inhibit their molecular target.

Biochem/physiol Actions

Ibandronate sodium inhibits farnesyl diphosphate synthase (IC₅₀ = 20 nM). Ibandronate sodium is also a bone resorption inhibitor. It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.

Ibandronate sodium is a farnesyl diphosphate synthase inhibitor (IC₅₀ = 20 nM); also a bone resorption inhibitor.

Ibandronate is a nitrogen-containing bisphosphonate (N-BP). It potentially inhibits mevalonate pathway in osteoclasts. Thus, ibandronate is effectively used to treat osteoporosis and other bone-related diseases.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable