I1877

Isocitric Dehydrogenase (NADP) from porcine heart

Type I, 0.5-3.0 unit/mg solid (plus numerous enzyme activities associated with porcine heart)

• Synonym(s): threo-D_s-Isocitrate: NADP⁺ oxidoreductase, ICDH, IDH
• CAS Number: 9028-48-2
• UNSPSC Code: 12352204
• NACRES: NA.54
• EC Number: 232-835-3
• MDL number: MFCD00131420
• EC Number: 1.1.1.42 (BRENDA, IUBMB)
• Specific activity: 0.5-3.0 unit/mg solid (plus numerous enzyme activities associated with porcine heart)
• Biological source: Porcine heart

Properties

• biological source: Porcine heart
• Quality Segment: 200
• type: Type I
• form: solid
• specific activity: 0.5-3.0 unit/mg solid (plus numerous enzyme activities associated with porcine heart)
• storage temp.: −20°C

Description

Biochem/physiol Actions

Isocitrate dehydrogenase (IDH) plays a major role in the Krebs cycle by catalyzing the oxidative decarboxylation of isocitrate. The oxidative decarboxylation of isocitrate generates α-ketoglutarate and NADPH. NADPH produced is essential for the production of fatty acids and cholesterol. This NADP-dependent molecules serves as homodimers.

Analysis Note

Crude

Other Notes

One unit will convert 1.0 μmole of isocitrate to α-ketoglutarate per min at pH 7.4 at 37°C.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H334
• pcodes: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)