This product has not been tested for solubility in DMSO. However, other sources suggest that this compound can be solubilized in DMSO at approximately 10 mg/mL. This information has not been validated.
I1656
Idarubicin hydrochloride
Topoisomerase II inhibitor, solid
Synonym(s):
(7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione, 4-Demethoxydaunorubicin hydrochloride, DMDR, IMI-30, Idamycin
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About This Item
Empirical Formula (Hill Notation):
C26H27NO9 · HCl
CAS Number:
Molecular Weight:
533.95
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
260-990-7
MDL number:
Form:
solid
Pricing and availability is not currently available.
Product Name
Idarubicin hydrochloride, solid
form
solid
originator
Johnson & Johnson
shipped in
wet ice
storage temp.
2-8°C
SMILES string
[H][C@@]1(C[C@@](O)(Cc2c(O)c3C(=O)c4ccccc4C(=O)c3c(O)c12)C(C)=O)O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5
InChI
1S/C26H27NO9/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3/t10-,15-,16-,17-,21+,26-/m0/s1
InChI key
XDXDZDZNSLXDNA-TZNDIEGXSA-N
Gene Information
human ... TOP2A(7153)
Application
Idarubicin is an anthracycline antibiotic that is an anti-leukemia agent with higher DNA binding capacity and greater cytotoxicity than daunorubicin.
Biochem/physiol Actions
Topoisomerase II inhibitor
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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This Item | |||
|---|---|---|---|
| form solid | form - | form solid | form solid |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| originator Johnson & Johnson | originator - | originator - | originator - |
| shipped in wet ice | shipped in - | shipped in - | shipped in - |
| Gene Information human ... TOP2A(7153) | Gene Information human ... TOP2A(7153) | Gene Information - | Gene Information - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 2 - Repr. 1B
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Is this soluble in DMSO, if yes then what conc.?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the mode of action for idarubicin?
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Idarubicin is an intercalating analog of daunorubicin that interferes with nucleic acid synthesis. It is an anti-tumor antibiotic used in the treatment of leukemia.
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How is idarubicin used therapeutically?
1 answer-
Idarubicin is an antineoplastic drug used to treat AML (Acute Myeloid Leukemia). In addition this compound has also been used in the treatment of breast cancer, non-Hodgkin's lymphoma, and both acute nonlymphocytic and chronic myelogenous leukemias.
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What can be used to make a solution of Idarubicin hydrochloride, Product I1656?
1 answer-
We test the solubility of idarubicin hydrochloride at 20 mg/ml of methanol. Idarubicin hydrochloride is also slightly soluble in water (10 mg/ml water with slight heat) and slightly soluble in ethanol.
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