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(2-Hydroxypropyl)-β-cyclodextrin solution

Name: (2-Hydroxypropyl)-β-cyclodextrin solution
Brand: SIGMA

Synonym(s):

Hydroxypropyl-β-cyclodextrin

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About This Item

Linear Formula:

(C₆H₉O₅)₇· (C₃H₇O)_4.5

NACRES:

NA.77

PubChem Substance ID:

24895710

UNSPSC Code:

12352201

MDL number:

MFCD00069372

Form:

solution (clear, colorless)

Pricing and availability is not currently available.

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Properties

biological source

synthetic (organic)

Quality Segment

200

form

solution (clear, colorless)

mol wt

~1396 Da

concentration

45 % (w/v) in H₂O

storage temp.

2-8°C

SMILES string

CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O

InChI

1S/C105H196O56/c1-50(106)22-127-43-71-78-85(134-29-57(8)113)92(141-36-64(15)120)99(148-71)156-79-72(44-128-23-51(2)107)150-101(94(143-38-66(17)122)86(79)135-30-58(9)114)158-81-74(46-130-25-53(4)109)152-103(96(145-40-68(19)124)88(81)137-32-60(11)116)160-83-76(48-132-27-55(6)111)154-105(98(147-42-70(21)126)90(83)139-34-62(13)118)161-84-77(49-133-28-56(7)112)153-104(97(146-41-69(20)125)91(84)140-35-63(14)119)159-82-75(47-131-26-54(5)110)151-102(95(144-39-67(18)123)89(82)138-33-61(12)117)157-80-73(45-129-24-52(3)108)149-100(155-78)93(142-37-65(16)121)87(80)136-31-59(10)115/h50-126H,22-49H2,1-21H3

InChI key

DCQLZTSRKLWEAB-UHFFFAOYSA-N

Description

General description

2-hydroxypropyl-β-cyclodextrin is obtained by chemical modification of cyclic oligosaccharide, β-cyclodextrins. It is used as a potential adjuvant for vaccines. 2-hydroxypropyl-β-cyclodextrin in an aqueous buffer increases the solubility of drugs. It is non-toxic in mice and rabbits. The formation of drug/cyclodextrin complexes is a rapidly reversible reaction and complexes exist both in solution and crystalline states. Solutions of many such complexes may be lyophilized to produce freely soluble powders which may be compressed into tablets.

Application

(2-Hydroxypropyl)-β-cyclodextrin solution has been used:

to prepare a fresh solution of Cdc42 activity-specific inhibitor (CASIN) drug for analysis of the epigenetic aging signature in C57BL/6 mice
to prepare the solution of remodelin and remodelin Fluor for assessment of remodelin toxicity in vivo in mice
as a constituent of sodium citrate solution for reconstitution of carfilzomib (PR-171)

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1 of 1

This Item	332607	389145	C0926
Sigma-Aldrich H5784 (2-Hydroxypropyl)-β-cyclodextrin solution	Sigma-Aldrich 332607 (2-Hydroxypropyl)-β-cyclodextrin	Sigma-Aldrich 389145 (2-Hydroxypropyl)-β-cyclodextrin	Sigma-Aldrich C0926 (2-Hydroxypropyl)-β-cyclodextrin
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 300
storage temp. 2-8°C	storage temp. -	storage temp. -	storage temp. room temp
form solution (clear, colorless)	form powder	form powder	form powder
mol wt ~1396 Da	mol wt average M_w ~1,460	mol wt average M_w ~1,540	mol wt 1396 Da
concentration 45 % (w/v) in H₂O	concentration -	concentration -	concentration -
biological source synthetic (organic)	biological source -	biological source -	biological source corn starch

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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