G3643
α1-Acid Glycoprotein from bovine plasma
≥99%
Synonym(s):
Orosomucoid
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About This Item
Form:
powder
Assay:
≥99%
Biological source:
bovine plasma
Pricing and availability is not currently available.
biological source
bovine plasma
Quality Segment
assay
≥99%
form
powder
technique(s)
electrophoresis: suitable, mass spectrometry (MS): suitable
UniProt accession no.
storage temp.
2-8°C
Gene Information
bovine ... ORM1(497200)
General description
α1-Acid glycoprotein (AGP, orosomucoid) is the major plasma glycoprotein with a molecular weight of 41-43 kDa. It is responsible for possessing the complex type of glycans.[1]
α1-Acid Glycoprotein (AGP, orosomucoid) from bovine plasma belongs to ‘lipocalins′ family which binds and transports small hydrophobic molecules. AGP is further classified into the subfamily ‘immunocalins′ which immunomodulates the inflammatory reactions. AGP is primarily produced in the liver, in few extra hepatic tissues and is present in neutrophil granules. Healthy cattle possesses 0.3 mg of AGP/ ml of concentrated serum.
Application
α1-Acid glycoprotein was used to study nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine[2]
α1-Acid Glycoprotein (AGP) from bovine plasma has been used:
- in mass spectrometry analysis to confirm the presence of Neu5Ac and Neu5Gc distribution in human and bovine AGP respectively
- for pretreating the microvessel before perfusing the MDA-MB-231 cells for tumor adhesion studies
- in the composition of tear model[3]
- as a reference in sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)
Biochem/physiol Actions
α1-Acid Glycoprotein from bovine plasma is an acute phase protein. It has anti-inflammatory potential and its concentration increases several folds during injury. AGP increases the chemotactic activity and life span of monocytes and inhibits neutrophil degranulation. Serum AGP levels differentiates sepsis from systemic inflammatory response syndrome (SIRS).
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This Item | |||
|---|---|---|---|
| biological source bovine plasma | biological source human plasma | biological source human plasma | biological source human plasma |
| technique(s) electrophoresis: suitable, mass spectrometry (MS): suitable | technique(s) ELISA: suitable | technique(s) - | technique(s) electrophoresis: suitable |
| assay ≥99% | assay ≥99% (agarose gel electrophoresis) | assay ≥95% (SDS-PAGE) | assay ≥90% (SDS-PAGE) |
| form powder | form powder | form lyophilized | form lyophilized powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. - | UniProt accession no. |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
Storage Class
13 - Non Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| G3643-25MG | 04061833630051 |
| G3643-250MG | 04061833630044 |
| G3643-100MG | 04061833271209 |