This product is a multicomponent material. A single CAS number does not apply. The starting materials are α-Glycerophosphate Dehydrogenase, CAS 9075-65-4, and Triosephosphate Isomerase, CAS 9023-78-3. The ammonium sulphate CAS is 7783-20-2.
G1881
α-Glycerophosphate Dehydrogenase-Triosephosphate Isomerase from rabbit muscle
Type III, ammonium sulfate suspension
Synonym(s):
GDH/TIM, α-GDH-TPI
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About This Item
Biological source:
rabbit muscle
Pricing and availability is not currently available.
biological source
rabbit muscle
Quality Segment
type
Type III
form
ammonium sulfate suspension
GDH activity
75-200 units/mg protein (biuret)
TPI activity
750-2000 units/mg protein
storage temp.
2-8°C
General description
Research area: Neuroscience
α-Glycerophosphate Dehydrogenase-Triosephosphate isomerase (α-GDH-TPI or GDH/TIM) is an enzyme mixture of α-glycerophosphate dehydrogenase (GDH) and triosephosphate isomerase (TPI).
α-Glycerophosphate Dehydrogenase-Triosephosphate isomerase (α-GDH-TPI or GDH/TIM) is an enzyme mixture of α-glycerophosphate dehydrogenase (GDH) and triosephosphate isomerase (TPI).
Application
α-glycerophosphate dehydrogenase was used in 2-deoxy-ribose 5-phosphate aldolase (DERA) cleavage (retroaldol) assay.[1]
α-Glycerophosphate Dehydrogenase-Triosephosphate Isomerase from rabbit muscle has been used in spectrophotometric aldolase assay and fructose 2,6 bisphosphate assay.[2] It has also been used in erythrocyte transketolase (ETK) activity to study the prevalence of and factors associated with thiamin deficiency in obese.
Biochem/physiol Actions
α-Glycerophosphate dehydrogenase (α-GPDH) has the ability to produce reactive oxygen species (ROS), that is induced by Ca2+.
α-glycerophosphate dehydrogenase catalyzes the conversion of dihydroxyacetone to glycerol phosphate[3]. α-Glycerophosphate dehydrogenase (α-GPDH) has the ability to produce reactive oxygen species (ROS), that is induced by Ca2+. Triosephosphate isomerase (TPI) is an essential enzyme in the glycolytic pathway, responsible for converting dihydroxyacetone phosphate (DHAP) into glyceraldehyde-3 phosphate (GAP). TPI′s role is crucial in enhancing the efficiency of the catabolic process within glycolysis. However, a deficiency in TPI can lead to glycolytic enzymopathies, rare genetic disorders characterized by neurologic dysfunction and hemolytic anemia.
Packaging
(Sold on the basis of α-GDH units.)
Physical form
Mixed crystalline suspension in 3.2 M (NH4)2SO4, with 0.05 g/L EDTA, pH 6.0
Other Notes
(α-GDH) One unit will convert 1.0 μmole of dihydroxyacetone phosphate to α-glycerophosphate per min at pH 7.4 at 25 °C.
(TPI) One unit will convert 1.0 μmole of D-glyceraldehyde 3-phosphate to dihydroxyacetone phosphate per min at pH 7.6 at 25 °C.
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This Item | |||
|---|---|---|---|
| biological source rabbit muscle | biological source rabbit muscle | biological source rabbit muscle | biological source rabbit muscle |
| form ammonium sulfate suspension | form ammonium sulfate suspension | form ammonium sulfate suspension | form ammonium sulfate suspension |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| GDH activity 75-200 units/mg protein (biuret) | GDH activity - | GDH activity - | GDH activity - |
| type Type III | type Type III-S | type Type I | type - |
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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