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Key Documents

C4124

Sigma-Aldrich

Chromium picolinate

≥98% (HPLC)

Synonym(s):

Cr(pic)3, CrPic

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About This Item

Empirical Formula (Hill Notation):
C18H12CrN3O6
CAS Number:
Molecular Weight:
418.30
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.25

biological source

synthetic

Assay

≥98% (HPLC)

form

powder

loss

≤5% loss on drying

storage temp.

room temp

SMILES string

O=C(O[Cr](OC(=O)c1ccccn1)OC(=O)c2ccccn2)c3ccccn3

InChI

1S/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3

InChI key

CBDQOLKNTOMMTL-UHFFFAOYSA-K

General description

Chromium picolinate is a supplemental or alternative medication for type 2 diabetes and an anti-diabetic mechanisms of CrPic in insulin-resistant 3T3-L1 adipocytes.

Application

Chromium picolinate (CrPic), a dietay supplement, may be used to study its potential as a modulator of glucose uptake and the activity of insulin. CrPic is used to study its effects on nuclear factor-κ B (NF-κB) and nuclear factor-E2-related factor-2 (Nrf2) pathways in animals.

Biochem/physiol Actions

Chromium picolinate (CrPic) is a supplemental or alternative medication for type 2 diabetes. Experimental evidence shows the effect of CrPic on glucose uptake through the activation of p38 MAPK. Chromium is thought to potentiate the action of insulin, leading to increased insulin sensitivity in type 2 diabetes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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C L Depew et al.
Journal of dairy science, 81(11), 2916-2923 (1998-12-05)
Forty-two Holstein calves were used to study performance and metabolic responses when milk replacer and then postweaning starter were supplemented with 1 ppm of Cr as Cr-tripicolinate. From birth through 8 wk of age, supplemental Cr tended to improve the
D J Appleton et al.
Journal of feline medicine and surgery, 4(1), 13-25 (2002-03-01)
The effect of dietary chromium supplementation on glucose and insulin metabolism in healthy, non-obese cats was evaluated. Thirty-two cats were randomly divided into four groups and fed experimental diets consisting of a standard diet with 0 ppb (control), 150 ppb
T L Ward et al.
Journal of animal science, 75(4), 1001-1008 (1997-04-01)
An experiment was conduct to determine the interactive effects of dietary chromium tripicolinate (CrPic), CP, and pen space (PS) as a stress on growth performance, carcass traits, and plasma hormones and metabolites of crossbred growing-finishing pigs (128 pigs; initial BW
E A Ott et al.
Journal of animal science, 77(11), 3022-3030 (1999-11-24)
Thoroughbred and Quarter Horse yearlings (n = 24; 335+/-7 d of age) were used in a 112-d feeding trial to determine whether chromium (Cr) supplementation would alter growth, development, and energy metabolism of growing horses on high-concentrate diets. The horses
L R Gentry et al.
Journal of animal science, 77(5), 1284-1294 (1999-05-26)
Thirty-two Suffolk wether lambs were fed for 84 d in a 2 x 2 factorial experiment using two levels of dietary protein (9.0 to 12.1% CP, low protein, LP; or 12.8 to 14.4% CP, high protein, HP) and supplemental Cr

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