C1159

L-Cycloserine

≥95% (TLC), ketosphinganine synthetase inhibitor, powder

• Synonym(s): (S)-4-Amino-3-isoxazolidone
• Empirical Formula (Hill Notation): C₃H₆N₂O₂
• CAS Number: 339-72-0
• Molecular Weight: 102.09
• NACRES: NA.77
• PubChem Substance ID: 24278296
• eCl@ss: 32160406
• UNSPSC Code: 12352202
• EC Number: 206-427-0
• MDL number: MFCD00064324
• Beilstein/REAXYS Number: 80799

Properties

• Product Name: L-Cycloserine,
• assay: ≥95% (TLC)
• Quality Segment: 200
• form: powder
• mp: 146 °C
• solubility: H₂O: 50 mg/mg protein
• storage temp.: −20°C
• SMILES string: N[C@H]1CONC1=O
• InChI: 1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m0/s1
• InChI key: DYDCUQKUCUHJBH-REOHCLBHSA-N

Description

Biochem/physiol Actions

Blocks sphingosine biosynthesis by inhibition of ketosphinganine synthetase. Cytotoxicity toward neuroblastoma and medulloblastoma cells mediated by suppression of ganglioside synthesis.

L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)