A8843

AM580

≥98% (HPLC), RAR-α agonist, solid

• Synonym(s): 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid
• Empirical Formula (Hill Notation): C₂₂H₂₅NO₃
• CAS Number: 102121-60-8
• Molecular Weight: 351.44
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891374
• NACRES: NA.77
• MDL number: MFCD00673916
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• Product Name: AM580, ≥98% (HPLC)
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: solid
• storage temp.: −20°C
• SMILES string: CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc3ccc(cc3)C(O)=O
• InChI: 1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
• InChI key: SZWKGOZKRMMLAJ-UHFFFAOYSA-N
• Gene Information: human ... RARA(5914), RARB(5915)

Description

General description

AM580 is a retinobenzoic derivative and a RAR-α (retinoic acid receptor-α) agonist. It stimulates the maturation of granulocytes in NB4 promyelocytic leukemia cell line and APL (acute promyelocytic leukemia) blasts. AM580 suppresses endometrial cancer cell proliferation.

Application

Retinoid derivative used for gene expression studies of leukemia-retinoic acid receptor (PHL-RAR) cell line differentiation.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)