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A7687

Aloe-emodin

≥95% (HPLC)

Synonym(s):

1,8-Dihydroxy 3-hydroxymethylanthraquinone, 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone, 3-Hydroxymethylchrysazine, Rhabarberone

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About This Item

Empirical Formula (Hill Notation):
C15H10O5
CAS Number:
481-72-1
Molecular Weight:
270.24
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
24891267
EC Number:
207-571-7
Beilstein/REAXYS Number:
2059062
MDL number:
MFCD00017373
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biological source

plant root (Rheum palmatum)

Quality Segment

200

assay

≥95% (HPLC)

form

powder

technique(s)

HPLC: suitable

color

yellow to brown

storage temp.

2-8°C

SMILES string

OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1

InChI

1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2

InChI key

YDQWDHRMZQUTBA-UHFFFAOYSA-N

General description

Aloe-emodin is a hydroxyanthraquinone found naturally in aloe plants.

Application

Aloe-emodin has been used as a standard in high performance liquid chromatography (HPLC) for separation and identification of phenolic compounds in Aloe arborescens Miller var. natalensis Berger (Kidachi aloe).

Biochem/physiol Actions

Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.
Aloe-emodin exhibits antibacterial, antiviral, anti-inflammatory and hepatoprotective effects.

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This Item
93938Y0001596PHL89157
Aloe-emodin ≥95% (HPLC)

Sigma-Aldrich

A7687

Aloe-emodin

Aloe-emodin analytical standard

Supelco

93938

Aloe-emodin

Diacerein impurity B European Pharmacopoeia (EP) Reference Standard

Y0001596

Diacerein impurity B

Aloe-emodin phyproof® Reference Substance

PHL89157

Aloe-emodin

form

powder

form

-

form

solid

form

solid

technique(s)

HPLC: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

color

yellow to brown

color

light orange to dark orange

color

-

color

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

biological source

plant root (Rheum palmatum)

biological source

-

biological source

synthetic

biological source

-

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

-

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000547727
0000547726
0000547727
0000547726
0000491586

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Mildred Acevedo-Duncan et al.
International immunopharmacology, 4(14), 1775-1784 (2004-11-09)
Aloe-emodin (1,8-dihydroy-3-[hydroxymethyl]-anthraquione) purified from Aloe vera leaves has been reported to have antitumor activity. The objectives of our research were to determine how aloe-emodin regulates the cell cycle, cell proliferation and protein kinase C (PKC) during glioma growth and development.
Jun-ming Guo et al.
Acta pharmacologica Sinica, 28(12), 1991-1995 (2007-11-23)
The aim of this study was to investigate the effects of aloe-emodin, a natural compound from the root and rhizome of Rheum palmatum, on the growth of human cervical cancer cells, HeLa. HeLa cells were treated with various concentrations of
Radical-scavenging effects of Aloe arborescens Miller on prevention of pancreatic islet B-cell destruction in rats
Beppu H, et al.
Journal of Ethnopharmacology, 89(1), 37-45 (2003)
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Global Trade Item Number

SKUGTIN
A7687-25MG04061833386071

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