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N-Acetyl-L-tryptophan

Name: N-Acetyl-<SC>L</SC>-tryptophan
Brand: SIGMA

≥99% (TLC), suitable for ligand binding assays

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₄N₂O₃

CAS Number:

1218-34-4

Molecular Weight:

246.26

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24891081

NACRES:

NA.26

EC Number:

214-935-9

MDL number:

MFCD00065976

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Properties

Product Name

N-Acetyl-L-tryptophan,

assay

≥99% (TLC)

Quality Level

200

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

2-8°C

SMILES string

CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O

InChI

1S/C13H14N2O3/c1-8(16)15-12(13(17)18)6-9-7-14-11-5-3-2-4-10(9)11/h2-5,7,12,14H,6H2,1H3,(H,15,16)(H,17,18)/t12-/m0/s1

InChI key

DZTHIGRZJZPRDV-LBPRGKRZSA-N

Description

Biochem/physiol Actions

N-Acetyl-L-tryptophan (NAT, Ac-Trp-OH) is used a substance P NK1 tachykinin receptor antagonist. N-Acetyl-L-tryptophan is also used as a competitive inhibitor to identify, differentiate and characterized tryptophanase(s).

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This Item	L7002	A3626	A2010
Sigma-Aldrich A6376 N-Acetyl-L-tryptophan	Sigma-Aldrich L7002 L-Lysine p-nitroanilide dihydrobromide	Sigma-Aldrich A3626 N_α-Acetyl-L-ornithine	Sigma-Aldrich A2010 N_α-Acetyl-L-lysine
form powder	form powder	form powder	form powder
technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable
assay ≥99% (TLC)	assay ≥98% (TLC)	assay ≥98% (TLC)	assay ≥98% (TLC)
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
color white to off-white	color white to off-white	color colorless to white	color colorless to white

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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A substance P antagonist reduces axonal injury and improves neurologic outcome when administered up to 12 hours after traumatic brain injury.

James J Donkin et al.

Journal of neurotrauma, 28(2), 217-224 (2010-12-24)

Previous studies have demonstrated that the compound N-acetyl-L-tryptophan (NAT) reduces brain edema and improves functional outcome following traumatic brain injury (TBI). In this study we examined whether this effect was mediated via the neurokinin-1 receptor, and whether there was an

New tryptophanase inhibitors: towards prevention of bacterial biofilm formation.

Scherzer R, Gdalevsky GY, et al.

Journal of Enzyme Inhibition, 24, 350-355 (2009)

A substance P antagonist improves outcome when administered 4 h after onset of ischaemic stroke.

Renée J Turner et al.

Brain research, 1393, 84-90 (2011-04-07)

Previous studies have suggested that substance P (SP) plays a critical role in the development of brain oedema and functional deficits following traumatic brain injury and that SP receptor antagonism may improve outcome. No studies have described such a role

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Global Trade Item Number

SKU	GTIN
A6376-10G	04061832414966
A6376-25G	04061833382097

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