A2480
5α-Androstan-3β-ol
powder
Synonym(s):
3β-Hydroxy-5α-androstane
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About This Item
Empirical Formula (Hill Notation):
C19H32O
CAS Number:
Molecular Weight:
276.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
214-952-1
MDL number:
Form:
powder
biological source
synthetic (organic)
sterility
non-sterile
form
powder
solubility
DMSO: soluble 14 mg/mL at ≤60 °C, H2O: insoluble
shipped in
ambient
storage temp.
room temp
SMILES string
[H][C@@]12CC[C@@]3([H])[C@]4([H])CCC[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@H](O)C2
InChI
1S/C19H32O/c1-18-9-3-4-16(18)15-6-5-13-12-14(20)7-11-19(13,2)17(15)8-10-18/h13-17,20H,3-12H2,1-2H3/t13-,14-,15-,16-,17-,18-,19-/m0/s1
InChI key
DJTOLSNIKJIDFF-LOVVWNRFSA-N
Application
5α-Androstan-3β-ol has been used as a cortisone analog to test its effect on the voltage-dependent potassium channel (Kv) current.
Biochem/physiol Actions
mCAR (constitutive androstane receptor) inverse agonist; testosterone metabolite.
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
Andrea Toell et al.
Journal of cellular biochemistry, 85(1), 72-82 (2002-03-14)
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are members of the nuclear receptor superfamily that regulate target gene transcription in a ligand-dependent manner. CAR and PXR have a rather broad, overlapping set of ligands that range from natural
Ping Li et al.
British journal of pharmacology, 158(5), 1322-1329 (2009-08-26)
Potentiating neurosteroids are some of the most efficacious modulators of the mammalian GABA(A) receptor. One of the crucial interactions may be between the C20 ketone group (D-ring substituent at C17) of the neurosteroid, and the N407 and Y410 residues in
Yan Cai et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 15(1), 89-96 (2002-01-23)
Nuclear receptors constitutive androstane receptor (CAR) and pregnane X receptor (PXR) cross talk and serve as xenobiotic sensors to form a safety net against the toxic effects of harmful substances. Retinoid x receptor alpha (RXRalpha) dimerizes with CAR and PXR.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A2480-50MG | 04061833350317 |