A1651

Adenosine 3′-phosphate 5′-phosphosulfate lithium salt hydrate

≥60%

• Synonym(s): 3′-Phosphoadenosine 5′-phosphosulfate lithium salt, APPS, Active sulfate, PAPS
• Empirical Formula (Hill Notation): C₁₀H₁₅N₅O₁₃P₂S · xLi⁺ · yH₂O
• CAS Number: 109434-21-1
• Molecular Weight: 507.26 (free acid basis)
• Beilstein: 8181191
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• NACRES: NA.51

Properties

• form: powder
• Quality Level: 200
• concentration: ≥60%
• shipped in: dry ice
• storage temp.: −70°C
• InChI: 1S/C10H15N5O13P2S.4Li.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24;;;;;/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24);;;;;1H2/q;4*+1;/p-4/t4-,6-,7-,10-;;;;;/m1...../s1
• InChI key: UGODCLHJOJPPHP-AZGWGOJFSA-J

Description

Application

3′-Phosphoadenosine 5′-phosphosulfate (PAPS) is used as a universal sulfonate donor for in vivo sulfonation by sulfotransferases. PAPS is used for the sulfation of glycans. PAPS is also useful to study the distribution and function of its biological transporter(s).

Adenosine 3′-phosphate 5′-phosphosulfate lithium salt has been used in a study that cloned and characterized a mammalian lithium-sensitive bisphosphate 3′-nucleotidase inhibited by inositol 1,4-bisphosphate. Adenosine 3′-phosphate 5′-phosphosulfate lithium salt has also been used in a study to assess the golgi-resident PAP-specific 3′-phosphatase-coupled sulfotransferase assays.

Quality

Major impurities appear to be adenosine 3′,5′-diphosphate, sulfate and ammonia substitution products.

Caution

Rapid decomposition occurs when exposed to room temperature: up to 17% per day at 37 °C. We ship on dry ice to minimize decomposition in transit.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves