85976

Methoxypolyethylene glycol succinate N-hydroxysuccinimide

5,000, ≥90%

• Synonym(s): Polyethylene glycol, mono-Methyl polyethylene glycol succinate N-succinimidyl ester, O-Methyl-O′-succinylpolyethylene glycol 5,000 N-succinimidyl ester, PEG-succinimidyl succinate
• CAS Number: 78274-32-5
• UNSPSC Code: 12162002
• PubChem Substance ID: 57653073
• NACRES: NA.25
• MDL number: MFCD00131598

Properties

• Quality Segment: 100
• assay: ≥90%
• form: powder
• storage temp.: −20°C
• SMILES string: N1(C(=O)CCC1=O)OC(=O)CCC(=O)COCCO
• InChI: 1S/C11H15NO7/c13-5-6-18-7-8(14)1-4-11(17)19-12-9(15)2-3-10(12)16/h13H,1-7H2
• InChI key: OVPTZXRXNNJKSJ-UHFFFAOYSA-N

Description

Application

• Matrix metalloproteinases-2/9-sensitive peptide-conjugated polymer micelles for site-specific release of drugs and enhancing tumor accumulation: preparation and in vitro and in vivo evaluation. This study explores the use of Methoxypolyethylene glycol succinate N-hydroxysuccinimide (MPEG-S-NHS) for creating peptide-conjugated polymer micelles that are sensitive to matrix metalloproteinases-2/9. These micelles are designed for site-specific drug release and increased tumor targeting, showcasing a promising application in advanced drug delivery systems (Zhang X, Wang X, Zhong W, Ren X, Sha X, Fang X, 2016) [link].

Other Notes

Shearwater Polymers product

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)