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356R-1

Sigma-Aldrich

Cytokeratin 5 & 6 (EP24 & EP67) Rabbit Monoclonal Primary Antibody

Synonym(s):

CK 5/6, cytokeratin 5/6

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

conjugate

unconjugated

Quality Level

100
500

antibody product type

primary antibodies

clone

EP24 & EP67, monoclonal

manufacturer/tradename

Cell Marque™

control

mesothelioma, prostate, squamous cell carcinoma ((lung))

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... KRT5(3852)

Related Categories

General description

Twenty identified cytokeratins make up a complex family of intermediate filaments.1 Cytokeratin 5 (58kDa) & cytokeratin 6 (56kDa) are type II high molecular weight keratins that are expressed in a broad range of normal tissues including breast, prostate, mesothelium, skin and esophagus.1-3 Anti-Cytokeratin 5 & 6 is a useful immunohistochemical marker in the identification of mesothelioma and lung squamous cell carcinoma.1

Quality

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Linkage

Cytokeratin 5 & 6 Positive Control Slides, Product No. 356S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris buffer, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R Lersch et al.
Molecular and cellular biology, 9(9), 3685-3697 (1989-09-01)
The mitotically active basal layers of most stratified squamous epithelia express 10 to 30% of their total protein as keratin. The two keratins specifically expressed in these cells are the type II keratin K5 (58 kilodaltons) and its corresponding partner
Role of immunohistochemistry in distinguishing epithelial peritoneal mesotheliomas from peritoneal and ovarian serous carcinomas.
Ordo?ez, N.G.
Modern Pathology, 15, 6-10 (2002)
K Takahashi et al.
The Journal of biological chemistry, 270(31), 18581-18592 (1995-08-04)
The human type II keratin 6 (K6; 56 kDa) is expressed in a heterogeneous array of epithelial tissues under normal conditions, but is better known for its strong induction in stratified epithelia that feature an enhanced cell proliferation rate or
N G Ordóñez
The American journal of surgical pathology, 22(10), 1215-1221 (1998-10-20)
The immunohistochemical diagnosis of mesothelioma is commonly made by using a battery of antibodies that reacts with lung adenocarcinomas but not with epithelial mesotheliomas. Only recently have markers that are often expressed in mesotheliomas but not in adenocarcinomas been recognized.

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Antibodies as Raw Material

Trusted IVDR-ready supplier of high-quality Cell Marque™ antibodies for diagnostic pathology and IHC, ensuring reliability and expert support.

Antibodies as Raw Material

Trusted IVDR-ready supplier of high-quality Cell Marque™ antibodies for diagnostic pathology and IHC, ensuring reliability and expert support.

Antibodies as Raw Material

Trusted IVDR-ready supplier of high-quality Cell Marque™ antibodies for diagnostic pathology and IHC, ensuring reliability and expert support.

Antibodies as Raw Material

Trusted IVDR-ready supplier of high-quality Cell Marque™ antibodies for diagnostic pathology and IHC, ensuring reliability and expert support.

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