01930

Adenosine 5′-monophosphate disodium salt

≥99.0% (HPLC)

• Synonym(s): 5′-AMPdisodium salt,, Adenylic acid disodium salt, 5′-AMP-Na₂
• Empirical Formula (Hill Notation): C₁₀H₁₂N₅Na₂O₇P
• CAS Number: 4578-31-8
• Molecular Weight: 391.18
• Beilstein: 3586732
• EC Number: 224-961-2
• MDL number: MFCD00065023
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 329747374
• NACRES: NA.51

Properties

• biological source: microbial (Candida utilis); synthetic
• Assay: ≥99.0% (HPLC)
• form: powder
• optical activity: [α]20/D −43±2°, c = 1% in 0.5 M Na₂HPO₄ (dry matter)
• impurities: ≤26% water
• SMILES string: [Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C10H14N5O7P.2Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1
• InChI key: QGXLVXZRPRRCRP-IDIVVRGQSA-L

Description

Application

Adenosine 5′-monophosphate (5′-AMP) has many uses in nature. 5′-AMP is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). It may be used as a substrate by a variety of enzymes such as AMP-thymidine kinase (EC 2.7.1.114), AMP deaminase (EC 3.5.4.6) and 5′-nucleotidase (EC 3.1.3.5).

Adenosine 5′-monophosphate disodium salt has been used:

• as a dissolved organic phosphorus (DOP) compound to study its rate of hydrolysis in Escherichia coli lysates
• to induce calcium responses in Fura2-loaded osteoblast (C2-OB)
• as a nucleotide metabolite in the medium for the isolation, culture, and identification of glioma stem cells (GSCs)

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves