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3-tert-Butyl-4-hydroxyanisole

Name: 3-<I>tert</I>-Butyl-4-hydroxyanisole
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

2-tert-Butyl-4-methoxyphenol, 3-BHA, BHA

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₆O₂

CAS Number:

121-00-6

Molecular Weight:

180.24

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823293

EC Number:

204-442-7

Beilstein/REAXYS Number:

1867499

MDL number:

MFCD00040484

Pricing and availability is not currently available.

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Properties

Quality Segment

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1083100

API family

bha

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

COc1ccc(O)c(c1)C(C)(C)C

InChI

1S/C11H16O2/c1-11(2,3)9-7-8(13-4)5-6-10(9)12/h5-7,12H,1-4H3

InChI key

MRBKEAMVRSLQPH-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
3-tert-Butyl-4-hydroxyanisole is a synthetic antioxidant, widely used as a food additive to prevent oxidative deterioration of fats and oils.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

3-tert-Butyl-4-hydroxyanisole may be used as a pharmaceutical reference standard for the determination of the analyte in plasma samples using high-resolution capillary gas chromatography-mass spectrometry with selective ion monitoring.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAA0066 in the slot below. This is an example certificate only and may not be the lot that you receive.

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1 of 1

This Item	1083100	20021	PHR2336
Supelco PHR1306 3-tert-Butyl-4-hydroxyanisole	USP 1083100 3-tert-Butyl-4-hydroxyanisole	Sigma-Aldrich 20021 3-tert-Butyl-4-hydroxyanisole	Supelco PHR2336 2-tert-Butyl-4-hydroxyanisole
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) -	application(s) pharmaceutical small molecule
technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) -	technique(s) -	technique(s) -
Quality Level 300	Quality Level -	Quality Level 200	Quality Level 300
grade certified reference material, pharmaceutical secondary standard	grade pharmaceutical primary standard	grade -	grade certified reference material, pharmaceutical secondary standard
storage temp. 2-30°C	storage temp. -	storage temp. -	storage temp. 2-8°C
agency traceable to USP 1083100	agency -	agency -	agency traceable to USP 1083008

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Hazard Classifications

Aquatic Chronic 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of the antioxidant 3-tert.-butyl-4-hydroxyanisole in rat plasma using high-resolution gas chromatography?mass spectrometry

Bailey E, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 225(1), 83-89 (1981)

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Hye Jin Jung et al.

PloS one, 9(11), e112256-e112256 (2014-11-15)

Silver materials have been widely used in diverse fields. However, their toxicity and their mechanism, especially in different forms, have not been studied sufficiently. Thus, cytotoxicity, apoptosis, and interleukin-1beta (IL-1β) production were investigated using macrophage-like THP-1 cells in the presence

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Global Trade Item Number

SKU	GTIN
PHR1306-500MG	04061835233564

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