D1685

Docusate sodium

meets USP testing specifications

• Synonym(s): Docusate sodium salt, AOT, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Sodium bis(2-ethylhexyl) sulfosuccinate, Sulfobutanedioic acid bis(2-ethylhexyl ester) sodium salt, Sulfosuccinic acid bis(2-ethylhexyl) ester sodium salt, Dioctyl sulfosuccinate sodium salt
• Empirical Formula (Hill Notation): C₂₀H₃₇NaO₇S
• CAS Number: 577-11-7
• Molecular Weight: 444.56
• UNSPSC Code: 12161902
• NACRES: NA.21
• PubChem Substance ID: 24893514
• EC Number: 209-406-4
• Beilstein/REAXYS Number: 4117588
• MDL number: MFCD00012455

Properties

• agency: meets USP testing specifications
• Quality Segment: 200
• description: anionic
• assay: 99.0-100.5% anhydrous basis
• form: solid
• mol wt: 444.56 g/mol
• technique(s): protein quantification: suitable
• application(s): detection; pharmaceutical (small molecule)
• SMILES string: [Na+].CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S([O-])(=O)=O
• InChI: 1S/C20H38O7S.Na/c1-5-9-11-16(7-3)14-26-19(21)13-18(28(23,24)25)20(22)27-15-17(8-4)12-10-6-2;/h16-18H,5-15H2,1-4H3,(H,23,24,25);/q;+1/p-1
• InChI key: APSBXTVYXVQYAB-UHFFFAOYSA-M

Description

General description

Docusate sodium (sodium dioctylsulfosuccinate, DOSS) is commonly used as a surfactant, food additive and stool softener.

Application

Forms reverse micelles in hydrocarbon solvents; Suitable for the solubilization of the major myelin transmembrane proteolipid

Docusate sodium (DOSS, AOT) has been used in the preparation of the following:

• Luminescent ceramics (phosphors).
• Stock solution during the quantification of DOSS in sea food by using liquid chromatography tandem mass spectrometry (LC-MS/MS).
• AOT-water-isooctane reverse micelle system

It has also been used in a study to understand its effect on protein bioactivity, when it is co-encapsulates with proteins in polymer based microsphere systems.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H315,H318
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P362 + P364
• Hazard Classifications: Eye Dam. 1 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• ppe: dust mask type N95 (US), Eyeshields, Gloves