27102

Citric acid monohydrate

puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

• Synonym(s): 2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate
• Linear Formula: HOC(COOH)(CH₂COOH)₂ · H₂O
• CAS Number: 5949-29-1
• Molecular Weight: 210.14
• UNSPSC Code: 12352100
• NACRES: NA.21
• PubChem Substance ID: 57648219
• EC Number: 201-069-1
• Beilstein/REAXYS Number: 4018641
• MDL number: MFCD00149972
• Assay: 99.5-100.5% (based on anhydrous substance)
• Form: grit

Properties

• grade: puriss.
• Quality Segment: 200
• assay: 99.5-100.5% (based on anhydrous substance)
• form: grit
• quality: meets analytical specification of Ph. Eur., BP, USP, E330
• impurities: residual solvents, complies, ≤0.0005% heavy metals (as Pb), 7.5-8.8% water (Karl Fischer)
• ign. residue: ≤0.05% (as SO₄)
• pKa: (1) 3.13, (2) 4.76, (3) 6.4
• anion traces: chloride (Cl^-): ≤50 mg/kg, oxalate (as oxalic acid): ≤100 mg/kg, sulfate (SO₄^2-): ≤100 mg/kg
• cation traces: As: ≤1 mg/kg, Ca: ≤200 mg/kg, Cu: ≤10 mg/kg, Fe: ≤10 mg/kg, Hg: ≤1 mg/kg, Pb: ≤1 mg/kg, Zn: ≤10 mg/kg
• suitability: complies for appearance of solution, complies for identity (IR), complies for reaction against H₂SO₄
• functional group: carboxylic acid
• SMILES string: OC(CC(O)(C(O)=O)CC(O)=O)=O.O
• InChI: 1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2
• InChI key: YASYEJJMZJALEJ-UHFFFAOYSA-N

Description

General description

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be Δ_solH_m (298.15K, m = 0.0203molkg^-1) = (29061 ± 123)Jmol^-1

Application

Citric acid monohydrate may be used in the diltiazem hydrochloride (drug) and melt extruded Eudragit RS PO (polymer) formulations. It improves the solubility of drug in the polymer matrix. It may be used to prepare citrate buffer for use in the intravital microscopic studies of adhesion and aggregation of platelets.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H319,H335
• pcodes: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• flash_point_f: 345.0 °F - closed cup
• flash_point_c: 173.9 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves