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8.22299

Piperidine

for synthesis

Synonym(s):

Piperidine, Hexahydropyridine, Pentamethyleneimine, Azacyclohexane, Azinane

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About This Item

Empirical Formula (Hill Notation):
C5H11N
CAS Number:
Molecular Weight:
85.15
UNSPSC Code:
12352005
EC Index Number:
203-813-0
NACRES:
NA.22
MDL number:
Assay:
≥99% (GC)
Grade:
synthesis grade
Bp:
106 °C/1013 hPa
Vapor pressure:
34 hPa ( 20 °C)
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grade

synthesis grade

Quality Level

vapor pressure

34 hPa ( 20 °C)

assay

≥99% (GC)

form

liquid

autoignition temp.

320 °C

potency

276 mg/kg LD50, skin (Rabbit)

expl. lim.

1.5-10.3 % (v/v)

dilution

(for synthesis)

pH

12.6 (20 °C, 100 g/L in H2O)

kinematic viscosity

1.77 cSt(20 °C)

bp

106 °C/1013 hPa

mp

-10.8 °C

transition temp

flash point 16 °C

density

0.86 g/cm3 at 20 °C

storage temp.

2-30°C

SMILES string

N1CCCCC1

InChI

1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2

InChI key

NQRYJNQNLNOLGT-UHFFFAOYSA-N

General description

Piperidine is a heterocyclic amine with a six-membered ring containing five methylene bridges (-CH2-) and one amine bridge (-NH-). Numerous alkaloids, pharmaceuticals, agrochemicals, and synthetic and biological intermediates contain the piperidine moiety. The commercial applications of piperidine include: solvent for curing agents and epoxy resins. In organic synthesis, it serves as an intermediate.

Application

Piperidine is used:
  • As an organic structure-directing agent in the synthesis of titanoborosilicate precursor.
  • As stock solution with NMP (1-methyl-2-pyrrolidinone) to deprotect the Fmoc group in the preparation of N-methylated cyclic peptides.[1]

Features and Benefits

Piperidine is more basic than pyridine and also a good nucleophile.

Analysis Note

Assay (GC, area%): ≥ 99.0 % (a/a)
Density (d 20 °C/ 4 °C): 0.861 - 0.863
Water (K. F.): ≤ 0.50 %
Identity (IR): passes test

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This Item
10409457126176046
Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

grade

synthesis grade

grade

-

grade

biotech. grade

grade

analytical standard

assay

≥99% (GC)

assay

99%

assay

≥99.5%

assay

≥98.0% (GC), 98.0-102.0% (T)

form

liquid

form

-

form

liquid

form

-

density

0.86 g/cm3 at 20 °C

density

0.862 g/mL at 20 °C (lit.)

density

0.862 g/mL at 20 °C (lit.)

density

0.862 g/mL at 20 °C (lit.)

bp

106 °C/1013 hPa

bp

106 °C (lit.)

bp

106 °C

bp

106 °C (lit.)


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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

60.8 °F - closed cup

flash_point_c

16 °C - closed cup



Certificates of Analysis (COA)

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Synthesis of expanded titanosilicate MWW-related materials from a pure silica precursor
Moliner M and Corma A
Chemistry of Materials, 24(22), 4371-4375 (2012)
Jayanta Chatterjee et al.
Nature protocols, 7(3), 432-444 (2012-02-11)
This protocol presents a detailed description of the synthesis of N-methylated cyclic peptides. N-methylation is a powerful technique to modulate the physicochemical properties of peptides by introducing one or more methyl groups into the peptidic amide bonds. Together with peptide
Heterocyclic chemistry
Sainsbury M
Royal Society of Chemistry, 8 (2001)



Global Trade Item Number

SKUGTIN
822299917004027269564254
822299010004022536488257
822299250004022536488271
822299902304027269058067
822299050004022536488264
822299050104027269151102

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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