444221

MMP-1/MMP-9 Substrate

≥95% (HPLC), Fluorescent MMP Substrate, solid

• Synonym(s): MMP-1/MMP-9 Substrate, Fluorogenic
• Empirical Formula (Hill Notation): C₄₉H₆₈N₁₄O₁₂S
• Molecular Weight: 1077.22
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Properties

• Product Name: MMP-1/MMP-9 Substrate, Fluorogenic, An excellent quenched fluorescence substrate for MMP-1 and MMP-9.
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: yellow
• solubility: 50% acetic acid: 10 mg/mL
• fluorescence: λ_ex ~365 nm, λ_em ~450 nm
• shipped in: ambient
• storage temp.: −20°C

Description

General description

An excellent quenched fluorescence substrate for MMP-1 and MMP-9 (excitation maximum: 365 nm; emission maximum: 450 nm). Both enzymes cleave this substrate between Gly and Cys(Me), liberating a fluorescent cleavage product. Suitable for inhibitor screening and determining K_i values. Excitation max: ~365 nm; emission max: ~450 nm.

Biochem/physiol Actions

Cell permeable: no

Primary Target
MMP-1, MMP-9

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Other Notes

Bickett, D.M., et al. 1993. Anal. Biochem. 212, 58.

{DNP-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(N-Me-Abz)-NH₂[Cha = β-cyclohexylalanyl; Abz = 2-aminobenzoyl (anthraniloyl)]

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable