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MCI-186

Name: MCI-186
Brand: MM

A free radical scavenger and antioxidant that reduces post-ischemic brain injury.

Synonym(s):

MCI-186, 3-Methyl-1-phenyl-2-pyrazolin-5-one, PMP, Edaravone

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₀N₂O

CAS Number:

89-25-8

Molecular Weight:

174.20

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD00003138

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

Pricing and availability is not currently available.

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Properties

Quality Segment

100

description

Merck USA index - 14, 6713

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

cream

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3

InChI key

QELUYTUMUWHWMC-UHFFFAOYSA-N

Description

General description

A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC₅₀ = 15 µM). Inhibits mitochondrial permeability transition pore.

Biochem/physiol Actions

Cell permeable: no

Primary Target
A free radical scavenger and antioxidant

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 15 µM inhibiting iron-dependent peroxidation in rat brain homogenates

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Katare, R. G., et al. 2003. Am. J. Physiol.285, H2171.
Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
Nishi, H., et al. 1989. Stroke 20, 1236.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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This Item	475856	373402	324761
Sigma-Aldrich 443300 MCI-186	Sigma-Aldrich 475856 Mitochondrial Division Inhibitor, mdivi-1	Sigma-Aldrich 373402 Hedgehog Antagonist VIII	Sigma-Aldrich 324761 Elastase Inhibitor V
assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥99% (HPLC)
form solid	form solid	form solid	form solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 100 mg/mL	solubility DMSO: 10 mg/mL	solubility DMSO: 100 mg/mL	solubility DMSO: 50 mg/mL (Use only fresh DMSO.)

pictograms

GHS07

signalword

Warning

hcodes

H302,H319

pcodes

P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

Certificates of Analysis (COA)

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