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Cathepsin Inhibitor I

Name: Cathepsin Inhibitor I
Brand: MM

The Cathepsin Inhibitor I controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Cathepsin Inhibitor I, Z-FG-NHO-Bz, CATI -1

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₂₅N₃O₆

Molecular Weight:

475.49

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

>90% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated, protect from light

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Properties

Quality Segment

100

assay

>90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated, protect from light

color

white

solubility

DMSO: soluble, acetonitrile: soluble, ethanol: soluble

shipped in

ambient

storage temp.

10-30°C

Description

General description

Cell-permeable cysteine protease inhibitor. Inhibits cathepsin B (k₂/K_i = 8.9 x 10³ M^-1 sec^-1), cathepsin L (k₂/K_i = 3.8 x 10⁵ M^-1 sec^-1), cathepsin S (k₂/K_i = 4.2 x 10⁴ M^-1 sec^-1), and papain (k₂/K_i = 2.4 x 10³ M^-1 sec^-1).

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k₂/K_i = 8.9 x 10³ M^-1sec^-1), cathepsin L (k₂/K_i = 3.8 x 10⁵ M^-1sec^-1), cathepsin S (k₂/K_i = 4.2 x 10⁴ M^-1sec^-1), and papain (k₂/K_i = 2.4 x 10³ M^-1sec^-1). Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C).

Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cathepsin B

Product does not compete with ATP.

Reversible: no

k₂/K_i = 8.9 x 10³ M⁻¹sec⁻¹ for cathepsin B

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Z-Phe-Gly-NHO-Bz

Zhu, D. and Uckun, F.M. 2000. Clin. Cancer Res.6, 2064.
Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item	219419	219377	219426
Sigma-Aldrich 219415 Cathepsin Inhibitor I	Sigma-Aldrich 219419 Cathepsin Inhibitor III	Sigma-Aldrich 219377 Cathepsin K Inhibitor I	Sigma-Aldrich 219426 Cathepsin L Inhibitor II
description The Cathepsin Inhibitor I controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.	description The Cathepsin Inhibitor III controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.	description The Cathepsin K Inhibitor I controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.	description The Cathepsin L Inhibitor II controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
form solid	form solid	form lyophilized solid	form solid
assay >90% (HPLC)	assay >90% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 10-30°C	storage temp. 10-30°C	storage temp. −20°C	storage temp. −20°C
solubility ethanol: soluble, acetonitrile: soluble, DMSO: soluble	solubility DMSO: 5 mg/mL, ethanol: 1 mg/mL	solubility methanol: 1 mg/mL, DMSO: soluble	solubility DMSO: soluble, ethanol: 50 mg/mL

Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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