1.00681

Succinic acid

crystalline, EMPROVE^® ESSENTIAL, ChP, NF, JPE

• Synonym(s): Butanedioic acid
• Linear Formula: HOOCCH₂CH₂COOH
• CAS Number: 110-15-6
• Molecular Weight: 118.09
• EC Index Number: 203-740-4
• UNSPSC Code: 12352106
• Beilstein/REAXYS Number: 1754069
• MDL number: MFCD00002789

Properties

• Quality Level: 500
• agency: ChP, JPE, NF
• product line: EMPROVE^® ESSENTIAL
• assay: 99.0-100.5% (HPLC)
• form: crystalline, solid
• autoignition temp.: 470 °C
• technique(s): API processing | cocrystal formation: suitable, API processing | salt formation: suitable
• bp: 235 °C (lit.), 235 °C/1013 hPa
• mp: 184-186 °C (lit.)
• transition temp: flash point 206 °C
• solubility: 58 g/L
• density: 1.56 g/cm³ at 20 °C
• anion traces: chloride (Cl^-): ≤0.001%, phosphate (PO₄^3-): ≤0.001%, sulfate (SO₄^2-): ≤0.003%
• cation traces: As: ≤0.0002%, Fe: ≤5 ppm, heavy metals (as Pb): ≤0.0020%, heavy metals (as Pb): ≤5 ppm
• application(s): liquid formulation; pharma/biopharma processes; pharmaceutical; solid formulation
• storage temp.: 2-30°C
• SMILES string: OC(=O)CCC(O)=O
• InChI: 1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
• InChI key: KDYFGRWQOYBRFD-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Succinic acid is a commonly used ingredient in pharmaceutical applications. In such applications it has been used primarily for solid oral dosage forms.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H318
• pcodes: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable