901332

Polyester bis-MPA dendron 8 NHBoc, 1 azide (core)

generation 3

• Synonym(s): Bis-MPA dendron, PFd-G3-Azide-NH-BOC
• Empirical Formula (Hill Notation): C₁₀₅H₁₇₃N₁₁O₄₆
• Molecular Weight: 2325.54
• UNSPSC Code: 12352125
• NACRES: NA.23

Properties

• description: 8 NHBoc, 1 azide (core)
• Quality Level: 100
• form: solid
• mol wt: generation 3
• no. Surface Groups: 8
• color: white to off-white
• functional group: azide (core)
• storage temp.: −20°C

Description

General description

• Polymer architecture: Dendron
• End Group Functionality: Boc-protected amine
• Boc : tert-Butyloxycarbonyl
• Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid.

Application

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. After Boc deprotection, amine-functionalized dendrons can be readily used in EDC or DCC coupling reactions with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications. Additionally, the azide-core can be readily conjugated using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC) or strain-promoted alkyne-azide cycloaddition (SPAAC).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable