T0909

Tenoxicam

NSAID

• Synonym(s): 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide
• Empirical Formula (Hill Notation): C₁₃H₁₁N₃O₄S₂
• CAS Number: 59804-37-4
• Molecular Weight: 337.37
• MDL number: MFCD00083502
• UNSPSC Code: 12352202
• PubChem Substance ID: 24899922
• NACRES: NA.77

Properties

• Assay: ≥98% (perchloric acid titration)
• form: powder
• solubility: DMF: 25 mg/mL, clear, yellow-green
• SMILES string: O=C(NC1=NC=CC=C1)C2=C(O)C(SC=C3)=C3S(N2C)(=O)=O
• InChI: 1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
• InChI key: LZNWYQJJBLGYLT-UHFFFAOYSA-N

Description

Application

Tenoxicam has been used:

• as a non-steroidal anti-inflammatory agent (NSAID) to study its effects on root gravitropism in Arabidopsis thaliana
• as a standard in microanalysis of NSAIDs by spectrophotometry
• to test its effect on surface potential andmembrane fluidity modification in phosphoglyceride monolayers

Biochem/physiol Actions

Tenoxicam (TX) possesses antipyretic and analgesic effects. It elicits radical scavenging activity and has the potential to treat enkylosing spondylitis, extra-articular diseases, acute gout, and rheumatic diseases. It is also effective in treating primary dysmenorrhea, postpartum uterine contraction pain, and post-operation backaches. TX is capable of inhibiting prostaglandin synthesis.

Non-steroidal antiinflammatory drug (NSAID) with comparatively low risk of renal or hepatic toxicity.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301 + H311 + H331
• Precautionary Statements: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves