SML0902

MONNA

≥98% (HPLC)

• Synonym(s): N-((4-Methoxy)-2-naphthyl)-5-nitroanthranilic acid
• Empirical Formula (Hill Notation): C₁₈H₁₄N₂O₅
• Molecular Weight: 338.31
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: light orange to dark orange
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

MONNA is a TMEM16A (ANO1) calcium-activated chloride channel blocker.

MONNA is a TMEM16A (ANO1) calcium-activated chloride channel blocker. MONNA blocks rhTMEM16A (ANO1) channel currents in HEK293 cells with and IC₅₀ of 1.27 μM. The compound MONNA does not affect related human or mouse chloride channels bestrophin-1, CLC2 and CFTR at concentrations up to 10 μM.

MONNA (benzbromarone (Benzb) and N-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid) is a TMEM16A antagonists. It affects the liberation of sarcoplasmic reticulum (SR) calcium in human airway smooth muscle cells.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable