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SAB4700666

Sigma-Aldrich

Monoclonal Anti-Cytokeratin (Pan-reactive) antibody produced in mouse

clone C-11, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Mouse Anti-Cytokeratin, Pan-reactive Cytokeratin Detection

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

C-11, monoclonal

form

buffered aqueous solution

species reactivity

mammals

concentration

1 mg/mL

technique(s)

flow cytometry: suitable

isotype

IgG1

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... KRT1(3848)

General description

Cytokeratins also known as keratins are filament-forming proteins of epithelial cells. In humans, there are 54 cytokeratins. These proteins are divided in to two sub-categories such as acidic type I keratins and basic-to-neutral type II keratins.
The antibody C-11 reacts with Cytokeratin peptides 4, 5, 6, 8, 10, 13, 18. Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues.

Immunogen

Keratin-enriched preparation from human epidermoid carcinoma cell line A431

Application

Monoclonal Anti-Cytokeratin (Pan-reactive) antibody produced in mouse has been used in immunocytochemistry.
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 0.5 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem/physiol Actions

Cytokeratins play an essential role in normal tissue structure and function. It also facilitates the maintenance of cell mechanical integrity.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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New consensus nomenclature for mammalian keratins
Schweizer J
The Journal of Cell Biology, 174, 169-174 (2006)
Evaluation of a simple method for storage of blood samples that enables isolation of circulating tumor cells 96 h after sample collection
Apostolou P
Journal of biological research (Thessalonike?, Greece) (2017)
Panagiotis Apostolou et al.
Journal of biological research (Thessalonike, Greece), 24, 11-11 (2017-10-05)
Minimizing the effects of transportation on the properties of biological material is a major challenge for the scientific community. The viability of cells is important in cases where their study is urgent for evaluation of treatment response or for the
Cytokeratin expression, fibrillar organization, and subtle function in liver cells
Marceau N and Loranger A
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire, 73, 619-625 (1995)
Stefano Guadagni et al.
BMC cancer, 22(1), 660-660 (2022-06-17)
Patients with unresectable recurrent rectal cancer (RRC) or colorectal cancer (CRC) with liver metastases, refractory to at least two lines of traditional systemic therapy, may receive third line intraarterial chemotherapy (IC) and targeted therapy (TT) using drugs selected by chemosensitivity

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