SAB4504031

Anti-phospho-IRF-3 (pSer³⁹⁶) antibody produced in rabbit

affinity isolated antibody

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 47 kDa
• species reactivity: rat, mouse, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; western blot: 1:500-1:1000
• NCBI accession no.: Q14653
• UniProt accession no.: Q14653
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer396)
• Gene Information: human ... IRF3(3661)

Description

General description

IRF3 (interferon regulatory factor 3) is a transcription factor belonging to the IRF family and is involved in the innate immunity response against viruses and bacteria. The gene encoding IRF3 is localized on human chromosome 19q13.33.

Immunogen

The antiserum was produced against synthesized peptide derived from human IRF-3 around the phosphorylation site of Ser396.

Immunogen Range: 362-411

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

Activated IRF3 (interferon regulatory factor 3) influences the expression of type I interferons via the toll-like receptor (TLR3/4)-mediated signaling pathway. IRF3 can suppress glioma invasion, proliferation and migration. Studies have suggested that IRF3 may have characteristics of tumor suppression.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable