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Key Documents

M7027

Sigma-Aldrich

Methyl cellulose

viscosity: 15 cP, BioReagent, suitable for cell culture

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.75

biological source

synthetic (organic)

product line

BioReagent

form

powder

technique(s)

cell culture | mammalian: suitable

viscosity

12-18 cP, 2 % in H2O(20 °C)

solubility

water: 50 mg/mL, clear to hazy

SMILES string

[*]OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO[*])O[C@@H](O[*])[C@H](O[*])[C@H]2O[*])[C@H](O[*])[C@@H](O[*])[C@@H]1O[*]

InChI key

YLGXILFCIXHCMC-JHGZEJCSSA-N

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General description

Methyl cellulose is obtained by etherification of cellulose. This commercial cellulose ether exhibits amphiphilic properties and original physicochemical properties. Methyl cellulose is enzyme resistant, non-digestible, non-allergic, and non-toxic.

Application

Methyl cellulose has been used:
  • as a vehicle for metformin drug during oral gavage
  • as a component of mammary epithelial cell growth medium for mammosphere culture
  • as a supplement in spheroid 3D co-cultures for spheroid invasion assays using hanging drop protocol

Methyl cellulose is used to create semi-solid matrices, as a cell culture gel, for culture of colony forming cells such as CFU-G; CFU-GM; cells and other cells used in toxicity assays. Low viscosity, not for plaquing assays or cloning.

Biochem/physiol Actions

Methyl cellulose finds applications in various industries such as in the food industry it is used as an emulsifier, texturing agent, thickener, and gelling additive. Methyl cellulose is also used in various cosmetics and personal care products such as hair shampoos, hair styling products, liquid soaps, body washes, lotions and creams, and toothpaste to yield their characteristic thick consistency. In addition, it serves as an additive for pharmaceuticals and is used in the production of capsules for nutritional supplements. Methyl cellulose is used as an alternative to glycerol in a cryopreservation medium. It is used along with culture supplements to enhance proliferation and differentiation in multiple or single lineage-committed hematopoietic progenitor cells. This cellulose derivative also has the potential to prevent the loss of adhesive properties and cell functions of various cell types including human skin fibroblasts, human melanoma cells, and mouse lung fibroblasts cultured in suspension.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Barley beta-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts
Fuste NP, et al.
Carbohydrate Polymers, 389-398 (2019)
High throughput and automatic colony formation assay based on impedance measurement technique
Lei KF, et al.
Analytical and Bioanalytical Chemistry, 409(12), 3271-3277 (2017)
Chandler Warr et al.
ACS applied bio materials, 3(4), 2239-2244 (2020-05-30)
We report a non-cytotoxic resin compatible with and designed for use in custom high-resolution 3D printers that follow the design approach described in Gong et al., Lab Chip 17, 2899 (2017). The non-cytotoxic resin is based on a poly(ethylene glycol)
Large variability in the motility of spiroplasmas in media of different viscosities
Boudet JF, et al.
Scientific Reports, 8(1), 17138-17138 (2018)
Dissociated effect and Chemosensitive enhancement of tumor spheroids influenced by an electric field in a microdevice
Huang Chun-Hao, et al.
Biomedical Microdevices, 20(3), 70-70 (2018)

Protocols

Hematopoietic stem cell culture protocols for isolation, expansion, and differentiation of CD34+ cells including CFU assays.

Hematopoietic stem cell culture protocols for isolation, expansion, and differentiation of CD34+ cells including CFU assays.

Hematopoietic stem cell culture protocols for isolation, expansion, and differentiation of CD34+ cells including CFU assays.

Hematopoietic stem cell culture protocols for isolation, expansion, and differentiation of CD34+ cells including CFU assays.

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