D4434

Dichloromethylenediphosphonic acid disodium salt

osteoclastic activity inhibitor, powder

• Synonym(s): Cl₂MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP
• Linear Formula: CH₂O₆Cl₂Na₂P₂
• CAS Number: 22560-50-5
• Molecular Weight: 288.86
• NACRES: NA.77
• PubChem Substance ID: 24278371
• UNSPSC Code: 12352106
• EC Number: 245-078-9
• MDL number: MFCD01632786
• Form: powder

Properties

• Product Name: Dichloromethylenediphosphonic acid disodium salt,
• form: powder
• Quality Segment: 300
• solubility: water: 49.00-51.00 mg/mL, clear, colorless
• storage temp.: room temp
• SMILES string: [Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O
• InChI: 1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
• InChI key: HJKBJIYDJLVSAO-UHFFFAOYSA-L
• Gene Information: rat ... Man2a1(25478), Si(497756)

Description

Biochem/physiol Actions

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)