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363M-1

Sigma-Aldrich

PAX-8 (MRQ-50) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-50, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (363M-14)
vial of 0.5 mL concentrate (363M-15)
bottle of 1.0 mL predilute (363M-17)
vial of 1.0 mL concentrate (363M-16)
bottle of 7.0 mL predilute (363M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry: 1:50-1:200

isotype

IgG

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... PAX8(7849)

General description

PAX-8 is a transcription factor expressed during embryonic development of Müllerian organs, kidneys, and thyroid, with continued expression in some epithelial cell types of these mature tissues.PAX-8 is a useful marker for neoplasms of gynecologic renal and thyroidorigin.PAX-8 (MRQ-50) antibody targets the N-terminus of the PAX-8 molecule. This section of the protein is shared with other PAX proteins such as PAX-5 and PAX-6; thus, some cross-reactivity with these proteins may be observed as evidenced by the labeling of selected lymphocytes, and neuroendocrine cells.

Quality


IVD
IVD
IVD
RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Mark J Mentrikoski et al.
Applied immunohistochemistry & molecular morphology : AIMM, 22(9), 635-641 (2014-10-04)
Clear-cell renal cell carcinoma (CC-RCC) is the most common primary kidney malignancy, yet this morphology is not unique to renal primary tumors, as clear-cell variants of numerous nonrenal carcinomas of varying lineages exist. Therefore, because of CC-RCC's ability to metastasize
Inigo Espinosa et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 34(3), 257-265 (2015-04-07)
Breast carcinomas rarely metastasize to the ovary and are even more rarely present clinically as primary ovarian tumors. However, patients with breast cancer not infrequently develop independent primary ovarian carcinomas. In these cases, distinction between independent primaries and metastatic tumors
Meaghan L Barr et al.
Journal of clinical pathology, 68(1), 12-17 (2014-10-16)
Immunohistochemical stains have greatly improved the diagnostic accuracy of renal cell carcinoma (RCC) for primary and distant tumours. We evaluate a marker that has recently been incorporated in clinical practice, PAX-8, in primary and metastatic RCCs. Two distinct tissue microarrays
Nelson G Ordóñez
Advances in anatomic pathology, 19(3), 140-151 (2012-04-14)
PAX 8 is a transcription factor involved in the regulation of organogenesis of the thyroid gland, kidney, and Müllerian system. Recent studies have shown that, among tumors, PAX 8 is commonly expressed in epithelial tumors of the thyroid and parathyroid
Nathan J Bowen et al.
Gynecologic oncology, 104(2), 331-337 (2006-10-27)
Epithelial ovarian carcinomas develop from ovarian surface epithelia that undergo complex differentiation to form distinguishable phenotypes resembling those of the epithelia of the female urogenital regions. While previous studies have implicated regulatory developmental homeobox (HOX) genes in this process, other
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