Skip to Content
Merck
All Photos(1)

Documents

PHR1319

Supelco

Residual Solvent - Trichloroethylene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Trichloroethylene, TCE, Trichloroethene

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
ClCH=CCl2
CAS Number:
79-01-6
Molecular Weight:
131.39
Beilstein:
1736782
MDL number:
MFCD00000838
UNSPSC Code:
41116107
PubChem Substance ID:
329823304

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1601827

vapor density

4.5 (vs air)

vapor pressure

61 mmHg ( 20 °C)

CofA

current certificate can be downloaded

autoignition temp.

770 °F

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.476 (lit.)

bp

86.7 °C (lit.)

mp

−84.8 °C (lit.)

density

1.463 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

2-30°C

SMILES string

Cl\C=C(\Cl)Cl

InChI

1S/C2HCl3/c3-1-2(4)5/h1H

InChI key

XSTXAVWGXDQKEL-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Residual Solvent - Trichloroethylene belongs to the group of class 2 residual solvents. The use of class 2 solvents should be limited in drug substances, excipients, dietary ingredients, and official products because of the inherent toxicities of these residual solvents. Trichloroethylene is a volatile and chlorinated organic compound, which finds applications as a solvent and greasing agent.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA0678 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H350

Hazard Classifications

Carc. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

188.6 °F - closed cup

Flash Point(C)

87 °C - closed cup

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC8766
LRAB2955
LRAA0678

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 1

1 of 1

Residual Solvents Mixture - Class IIB Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1065

Residual Solvents Mixture - Class IIB

Michihiro Kamijima et al.
International archives of occupational and environmental health, 80(5), 357-370 (2006-11-16)
Workers exposed to trichloroethylene (TCE) rarely show severe generalized skin disorders and accompanying hepatitis which resemble drug hypersensitivities. The disorders are completely different from solvent-induced irritating contact dermatitis, and their serious consequences have become one of the critical occupational health
Hideaki Watanabe et al.
Dermatology (Basel, Switzerland), 221(1), 17-22 (2010-04-22)
Patients having a generalised rash with severe liver dysfunction associated with exposure to trichloroethylene (TCE) have been reported mainly in Asian countries. However, no case has been reported in Japan since the 1990s. Here, we describe a case of hypersensitivity
Cheryl Siegel Scott et al.
Environmental health perspectives, 114(9), 1471-1478 (2006-09-13)
A large body of epidemiologic evidence exists for exploring causal associations between cancer and trichloroethylene (TCE) exposure. The U.S. Environmental Protection Agency 2001 draft TCE health risk assessment concluded that epidemiologic studies, on the whole, support associations between TCE exposure
Shams Tabrez et al.
Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, 27(3), 178-196 (2009-08-07)
Trichloroethylene (TCE) is a prevalent occupational and environmental contaminant that has been reported to cause a variety of toxic effects. This article reviews toxicity, mutagenicity, and carcinogenicity caused by the exposure of TCE and its metabolites in the living system
Nagalakshmi Keshava et al.
Environmental health perspectives, 114(9), 1464-1470 (2006-09-13)
Peroxisome proliferator-activated receptor alpha (PPARalpha) is thought to be involved in several different diseases, toxic responses, and receptor pathways. The U.S. Environmental Protection Agency 2001 draft trichloroethylene (TCE) risk assessment concluded that although PPAR may play a role in liver
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service