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Key Documents

AB2082

Sigma-Aldrich

Anti-CD44v10 Antibody, exon v10

Chemicon®, from rabbit

Synonym(s):

Anti-CDW44, Anti-CSPG8, Anti-ECMR-III, Anti-HCELL, Anti-HUTCH-I, Anti-IN, Anti-LHR, Anti-MC56, Anti-MDU2, Anti-MDU3, Anti-MIC4, Anti-Pgp1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rabbit, canine, rat, human, bovine, mouse, pig

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
radioimmunoassay: suitable
western blot: suitable

NCBI accession no.

NM_000610.3
NM_001001389.1
NM_001001390.1
NM_001001391.1
NM_001001392.1

UniProt accession no.

P16070

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... CD44(960)

Specificity

CD44v10 Approximant 116 kDa)

Recent studies indicate that the expression of CD44 on the cell surface changes profoundly during tumor metastasis, particularly during the progression of various carcinomas. Sequencing analysis reveals that CD44 exists in different forms (at least 15 isoforms have been identified) that are variants of the common or standard hemopoietic form CD44s. Specifically, the human CD44 gene contains 19 exons, out of which 10 exons can potentially be alternatively spliced. In particular, CD44s contains exons 1-15 and exons 15-19. The other exons (e.g. 6-14) are also spliced in a variety of different cells. For example, epithelial cells contain exons 12-14 inserted into the CD44s transcripts. This isoform has been designated as CD44E. Other CD44 variants CD44v) have the same sequences at the two ends of the molecule, but differ in a middle region (with different numbers of additional exons) located on the external side of the cell membrane. It has been suggested that expression of CD44 variants with the additional exon 14 (so-called v10) is responsible for tumor progression and metastasis. In fact, CD44v10 expression has been used as an indicator of metastasis.

Immunogen

Epitope: exon v10
Synthetic peptide of human CD44v10

Application

ELISA: 1:2000
Flow Cytometry: 1:1000
Immunofluorescence: 1:200
Immunohistostaining of paraffin embedded tissue: 1:250
Immunoprecipitation: 1:200
Western Blotting: 1:1000
RIA: 1:5000

Optimal working dilutions must be determined by the end user.
This Anti-CD44v10 Antibody, exon v10 is validated for use in ELISA, FC, IP, RIA, WB, IC, IH(P) for the detection of CD44v10.

Linkage

Replaces: 04-1123

Physical form

Format: Purified
Purified immunoglobulin. Liquid in 10 mM sodium phosphate, 150 mM NaCl with 0.01% sodium azide.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Qian Guo et al.
The Journal of biological chemistry, 298(11), 102588-102588 (2022-10-16)
Cell adhesion molecule CD44v8-10 is associated with tumor ste0mness and malignancy; however, whether CD44v10 alone confers these properties is unknown. Here, we demonstrated that CD44v10 promotes stemness and chemoresistance of triple-negative breast cancers (TNBCs) individually. Next, we identified that genes
Qian Guo et al.
Oncology reports, 45(4) (2021-03-03)
The cell surface glycoprotein CD44 displays different active statuses; however, it remains unknown whether the activation process of CD44 is critical for tumor development and progression. The aim of the present study was to investigate whether breast cancer (BCa) cells with
Chih-Hung Guo et al.
Marine drugs, 19(4) (2021-04-04)
Fish oil (FO) and selenium (Se) possess antiangiogenic potential in malignant tumors. This study aimed to determine whether combination of FO and Se enhanced treatment efficacy of low-dose antiangiogenic agent Avastin (bevacizumab) in a dose-dependent manner and targeted multiple signaling
Milan Dastych et al.
Pathology oncology research : POR, 27, 614281-614281 (2021-07-15)
Background and aims: The majority of colorectal cancers arise from detectable adenomatous or serrated lesions. Here we demonstrate how deregulated alternative splicing of CD44 gene in diseased colon mucosa results in downregulation of standard isoform of CD44 gene (CD44s) and
DNA aptamers against exon v10 of CD44 inhibit breast cancer cell migration.
Iida, J; Clancy, R; Dorchak, J; Somiari, RI; Somiari, S; Cutler, ML; Mural, RJ; Shriver, CD
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