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Sigma-Aldrich

U0126

solid, suitable for kinase activity assay

Synonym(s):

Kinase inhibitor, MEK inhibitor

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About This Item

UNSPSC Code:
12352200
eCl@ss:
32160405
NACRES:
NA.41

product name

U0126, U0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.

Quality Level

100

form

solid

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_002755.2

UniProt accession no.

P36507
Q02750

shipped in

wet ice

Gene Information

human ... MAP2K1(5604)

Biochem/physiol Actions

Inhibitor Type: Kinase
Protein Target: MAPKK 1

Physical form

C18H16N6S2

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jahangir Iqbal et al.
The Journal of biological chemistry, 295(13), 4101-4113 (2020-02-13)
The hormone leptin regulates fat storage and metabolism by signaling through the brain and peripheral tissues. Lipids delivered to peripheral tissues originate mostly from the intestine and liver via synthesis and secretion of apolipoprotein B (apoB)-containing lipoproteins. An intracellular chaperone
Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes.
Scherle, P A, et al.
Journal of immunology (Baltimore, Md. : 1950), 161, 5681-5686 (1998)
Ashley Markazi et al.
mBio, 11(6) (2020-11-12)
Inflammation triggered by innate immunity promotes carcinogenesis in cancer. Kaposi's sarcoma (KS), a hyperproliferative and inflammatory tumor caused by Kaposi's sarcoma-associated herpesvirus (KSHV) infection, is the most common cancer in AIDS patients. KSHV infection sensitizes cells to pathogen-associated molecular patterns
Yi-Wei Lin et al.
Cell communication and signaling : CCS, 19(1), 69-69 (2021-07-02)
Intercellular communications are important for maintaining normal physiological processes. An important intercellular communication is mediated by the exchange of membrane-enclosed extracellular vesicles. Among various vesicles, exosomes can be detected in a wide variety of biological systems, but the regulation and
M F Favata et al.
The Journal of biological chemistry, 273(29), 18623-18632 (1998-07-11)
The compound U0126 (1,4-diamino-2,3-dicyano-1, 4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1 transactivation in a cell-based reporter assay. U0126 was also shown to inhibit endogenous promoters containing AP-1 response elements but did not affect genes lacking an AP-1 response element
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