1.09334

LiChrosorb^® RP-18 (10 µm)

HPLC sorbent

• Synonym(s): TM=["LiChrosorb"] C18 sorbent for HPLC
• UNSPSC Code: 41115709
• NACRES: SB.52
• Particle size: 10 μm
• Matrix active group: C18 (RP18), C18 bonding phase
• Pore size: 100 Å pore size
• Matrix: fully porous particle

Properties

• Product Name: LiChrosorb^® RP-18 (10 µm),
• material: stainless steel column
• agency: suitable for USP L1
• product line: LiChrosorb^®
• feature: endcapped: no
• analyte functional class(es): antibiotics, explosives, fat soluble vitamins, lipids, nutraceuticals and antioxidants, oils, pigments, sweeteners, water soluble vitamins
• analyte chemical class(es): PAHs, PCBs (aroclor identification), PFAS, aflatoxins, alcohols / fermentation, alcohols and aldehyde, aliphatic amines, alkaloids, amino acids, aromatic amines, cannabinoids as tms derivatives, carotenoids, catecholamines, coloring compounds, essential oils, esters, fatty acids, flavonoids, glycans, ketones, metabolized steroids, nitrosamines, nucleic acids, nucleosides, oligonucleotides, organic phosphates, peptides, pesticides, phenols, phospholipids, phthalate esters, preservatives, proteins, steroids (cholesteryl esters), sulfonamides
• parameter: 60 °C max. temp.
• technique(s): HPLC: suitable, mass spectrometry (MS): suitable (Low)
• matrix: fully porous particle
• matrix active group: C18 (RP18), C18 bonding phase
• particle size: 10 μm
• pore size: 100 Å pore size
• operating pH range: 2-7.5
• bulk density: 200‑400 kg/m³
• separation technique: reversed phase
• storage temp.: no temp limit

Description

Application

• High-performance liquid chromatographic determination of the antifungal drug fluconazole in plasma and saliva of human immunodeficiency virus-infected patients.: This study highlights a method using RP-18 for the determination of fluconazole, demonstrating the column′s effectiveness in bioanalytical contexts (Beijnen JH et al., 1995).


• Determination of serum aluminium using an ion-pair reversed-phase high-performance liquid chromatographic-fluorimetric system with lumogallion.: This research utilizes RP-18 to analyze serum aluminum, showcasing its utility in trace metal analysis in clinical samples (Ong CN et al., 1995).


• A radiochemical high-performance liquid chromatographic method for the analysis of 2-fluoro-2-deoxy-D-glucose-derived metabolites in human chondrocytes.: The method developed employs RP-18, underscoring its role in the radiochemical analysis of complex biological matrices (Greiling H et al., 1993).


• Systematic approach to the determination of cephalosporins in biological fluids by reversed-phase liquid chromatography.: This study demonstrates the application of RP-18 in the pharmacokinetic analysis of cephalosporins, further proving the column′s broad applicability in pharmaceutical analyses (Juge F et al., 1983).


• Simultaneous determination of 3,4-dihydroxyphenylalanine, 5-hydroxytryptophan, dopamine, 4-hydroxy-3-methoxyphenylalanine, norepinephrine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, serotonin, and 5-hydroxyindoleacetic acid in rat cerebrospinal fluid and brain by high-performance liquid chromatography with electrochemical detection.: This research uses RP-18 to simultaneously quantify multiple neurotransmitters, highlighting its sensitivity and specificity for neurochemical analysis (Huot S et al., 1982).

Analysis Note

Theoretical Plates (N/m) (Toluene): ≥ 25000
stability testing (performance): passes test
particle size (Malvern) (d10): 8.7 - 10.0 µm
particle size (Malvern) (d50): 12.0 - 14.0 µm
particle size (Malvern) (d90): 17.5 - 20.5 µm

Legal Information

LiChrosorb is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable