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T-075

Supelco

3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

3,3′,5′-Triiodo-L-thyronine, Reverse T3, rT(3)

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About This Item

Empirical Formula (Hill Notation):
C15H12I3NO4
CAS Number:
5817-39-0
Molecular Weight:
650.97
MDL number:
MFCD00036864
UNSPSC Code:
41116107
PubChem Substance ID:
329826619
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol with 0.1N NH3

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

N[C@@H](Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1

InChI key

HZCBWYNLGPIQRK-LBPRGKRZSA-N

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General description

Reverse T3, also known as rT3 or 3,3′,5′-Triiodo-L-thyronine, is a biologically inactive form of the thyroid hormone T3 and is produced in the body particularly during periods of stress. Under certain conditions such as fibromyalgia, liver disease, and chronic fatigue syndrome (CFS), more rT3 is produced which minimizes the desirable conversion of thyroxine (T4) to T3. Reverse T3 serum concentrations are measured by LC-MS/MS to monitor impact of these and other diseases on thyroid hormone levels.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

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Certificates of Analysis (COA)

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Bernt Rønning et al.
The Journal of experimental biology, 212(19), 3060-3067 (2009-09-15)
Young birds, in their post-natal growth period, may reduce their growth and metabolism when facing a food shortage. To examine how such responses can be mediated by endocrine-related factors, we exposed Japanese quail chicks to food restriction for either 2
Davide Gnocchi et al.
Steroids, 77(6), 589-595 (2012-03-01)
Thyroid hormones (THs) have a wide variety of essential roles in vertebrates, ranging from the regulation of key metabolic processes to cell proliferation and apoptosis. The classical mechanism of action of THs is genomic; 3,5,3'-triiodothyronine (T3) binds to specific nuclear
Hidenori Nagao et al.
The Journal of endocrinology, 210(1), 117-123 (2011-04-12)
Little is known about the kinetics and metabolism of thyroid hormones in the hypothyroid state. To investigate these factors, we developed a reliable method for measurement of serum thyroxine (T(4)), triiodothyronine (T(3)), reverse-T(3) (rT(3)) and stable isotope-labeled T(4) ([(13)C(9)]T(4)), using
Elena Grasselli et al.
The Journal of endocrinology, 210(1), 59-69 (2011-04-22)
Iodothyronines influence lipid metabolism and energy homeostasis. Previous studies demonstrated that 3,5-l-diiodothyronine (T(2)), as well as 3,3',5-L-triiodothyronine (T(3)), was able to both prevent and reverse hepatic steatosis in rats fed a high-fat diet, and this effect depends on a direct
[Total triiodothyronine (TT3), free triiodothyronine (FT3), reverse T3 (rT3)].
Tamio Ieiri
Nihon rinsho. Japanese journal of clinical medicine, 68 Suppl 7, 284-289 (2010-10-22)
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Protocols

Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

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