937819

Methoxy-poly(ethylene glycol) amine-block-poly-L-lysine hydrobromide

PEG average M_n 2000, PLLA average M_n 5000

• Synonym(s): Block copolymer, Drug delivery polymer, Polymeric micelles, Tissue engineering, Tumor imaging, mPEG-amine2k -PLL5k, mPEGNH₂-PLL (Hidden synonyms: Polymeric micelles, Block copolymer, Tumor imaging, Tissue engineering, Drug delivery polymer)
• Linear Formula: C₃H₉NO(OC₂H₄)_x-(C₆H₁₃N₂OBr)_n
• UNSPSC Code: 12162002
• NACRES: NA.21

Properties

• form: chunks
• Quality Level: 100
• mol wt: PEG average M_n 2000; PLLA average M_n 5000
• color: white
• storage temp.: 2-8°C
• SMILES string: COCCOCCNC(C(CCCC[NH3+])N[H])=O.[Br-]
• InChI: 1S/C11H25N3O3.BrH/c1-16-8-9-17-7-6-14-11(15)10(13)4-2-3-5-12;/h10H,2-9,12-13H2,1H3,(H,14,15);1H

Description

General description

Methoxy poly(ethylene glycol) amine-block-poly(L-lysine) (mPEG-PLL) is a cationic diblock copolymer consisting of amine-functionalized PEG and PLL that can be used in drug delivery applications. The cationic PLL block can bind to DNA or RNA, as well as other therapuetic agents, while the amine-functionalized PEG block can be further functionalized with targeting moieties for targeted and controlled drug delivery. This cationic diblock copolymer can self-assemble in the presence of a drug to form polymeric micelles and polymersomes.

Application

*Non-viral gene delivery application
*Targeted drug delivery application
*Protein coatings and tissue culture

Features and Benefits

*Self-assemble capability to form micelles and polymersomes
*Amine functional group at the side chain enables further rapid functionalization
*Cationic poly(L-lysine) has excellent DNA and RNA condensation property
*Biodegradable, biocompatible and water soluble

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable