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Key Documents

905283

Sigma-Aldrich

(6-Aminohexyl)triphenylphosphonium bromide hydrobromide

≥95%

Synonym(s):

Aminohexane TPP mitochondrial tag, Mitochondria-targeting probe building block, Phosphonium lipocation tag

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About This Item

Empirical Formula (Hill Notation):
C24H29BrNP · xHBr
Molecular Weight:
442.37 (free base basis)
UNSPSC Code:
12352101
NACRES:
NA.22

Assay

≥95%

form

solid

reaction suitability

reagent type: ligand

functional group

phosphine

storage temp.

2-8°C

Application

Mitochondria perform several functions in the cell, and dysfunction has been implicated in various organ systems and disease states, including neurodegenerative disorders and cancers. The targeting of small molecules to the mitochondria can help to probe and better understand this relationship. This aminohexane triphenylphosphine (TPP) tag is conjugated to small molecules to localize them to the mitochondria in cells where the TPP cations facilitate both cellular uptake and accumulation in the mitochondria.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Michael P Murphy
Biochimica et biophysica acta, 1777(7-8), 1028-1031 (2008-04-29)
Mitochondrial function and dysfunction contributes to a range of important aspects of biomedical research. Consequently there is considerable interest in developing approaches to modify and report on mitochondria in cells and in vivo. One approach has been to target bioactive

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