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V6627

Sigma-Aldrich

Anti-Vascular Endothelial Growth Factor antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym(s):

Anti-VEGF

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About This Item

MDL number:
MFCD00282511
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL
neutralization: suitable
western blot: 1-2 μg/mL

UniProt accession no.

P15692

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... VEGFA(7422)

Specificity

The antibody will neutralize the biological activity of recombinant human VEGF165 and recombinant human VEGF121. The antibody shows ~20% cross-reactivity with recombinant mouse VEGF and recombinant rat VEGF.

Immunogen

recombinant human VEGF.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Markus Theurl et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(9), 4815-4823 (2018-06-20)
The pathogenesis of diabetic neuropathy remains enigmatic. Damage to the vasa nervorum may be responsible for this disorder. Recently, we showed that secretoneurin (SN) induces angiogenesis in hindlimb and myocardial ischemia. Moreover, beneficial effects were observed in wound healing. We
Jertta-Riina Sarkanen et al.
Frontiers in pharmacology, 1, 147-147 (2010-01-01)
The developed standardized human cell based in vitro angiogenesis assay was intra-laboratory pre-validated to verify that the method is reliable and relevant for routine testing of modulators of angiogenesis, e.g., pharmaceuticals and industrial chemicals. This assay is based on the
Henning Ulrich et al.
Frontiers in pharmacology, 9, 500-500 (2018-06-06)
Bone marrow metastasis occurs in approximately 350,000 patients that annually die in the U.S. alone. In view of the importance of tumor cell migration into the bone marrow, we have here investigated effects of various concentrations of stromal cell-derived factor-1
Laijian Sui et al.
Frontiers in cell and developmental biology, 12, 1374269-1374269 (2024-08-05)
The present study aimed to investigate the involvement of aberrant BMP8A expression in TNBC and bone metastasis. Aberrant expression of BMP8A in breast cancer was first determined by analyzing The Cancer Genome Atlas breast cancer cohort (TCGA-BRCA) and an immunohistochemical
Ilnur I Salafutdinov et al.
Biomedicines, 11(7) (2023-07-29)
The biosafety of gene therapy remains a crucial issue for both the direct and cell-mediated delivery of recombinant cDNA encoding biologically active molecules for the pathogenetic correction of congenital or acquired disorders. The diversity of vector systems and cell carriers
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