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T8761

Sigma-Aldrich

Tyloxapol

nonionic surfactant

Synonym(s):

4-(1,1,3,3-Tetramethylbutyl)phenol polymer with formaldehyde and oxirane

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About This Item

CAS Number:
25301-02-4
MDL number:
MFCD00149002
UNSPSC Code:
12161900
PubChem Substance ID:
24900557
NACRES:
NA.25

Quality Level

200

CMC

0.018 mM

transition temp

cloud point 94.3 °C

SMILES string

[H]C([H])=O.OCCO.CC(C)(C)CC(C)(C)c1ccc(O)cc1

InChI

1S/C14H22O.C2H6O2.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;3-1-2-4;1-2/h6-9,15H,10H2,1-5H3;3-4H,1-2H2;1H2

InChI key

GWJOFBXSBDVUMH-UHFFFAOYSA-N

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General description

A nonionic liquid polymer of the alkyl aryl polyether alcohol type. Used as a surfactant.

Application

Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction. Tyloxapol is used in the development of non-ionic surfactant-based liposomes (niosomes) for use in drug delivery systems. Tyloxapol may be used to study its mechanism of protecting macrophages from endotoxins. Tyloxapol may be used to study is potential cell toxicitiy.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Jung-Hua Steven Kuo et al.
Colloids and surfaces. B, Biointerfaces, 64(2), 208-215 (2008-03-14)
Tyloxapol is reported to prevent macrophages from reacting to endotoxin. However, the intracellular responses that tyloxapol induces in macrophages are still not fully explored. Hence, the objective of this study was to evaluate the intracellular events in macrophages treated with
Jung-hua Steven Kuo et al.
Pharmaceutical research, 23(7), 1509-1516 (2006-06-17)
Tyloxapol, a viscous polymer of the alkyl aryl polyether alcohol type, is classified as a nonionic surfactant and is widely used in biomedical applications. Although tyloxapol has been reported to be cytotoxic in various cell lines, there is no published
Maciej Gawlik et al.
Environmental toxicology and pharmacology, 33(3), 386-393 (2012-03-06)
The toxicity of carcinogenic benzo(a)pyrene (BaP) can be intensified by the pro-oxidative effects of metabolic activation. The oxidatively active products can be formed during enzymatic biotransformation or in the process of co-oxygenation with lipid peroxidation. This study assesses if the
M Saravanan et al.
Pharmaceutical biology, 49(10), 1074-1081 (2011-05-20)
Ichnocarpus frutescens (L.) R.Br. (Apocynaceae) is used to treat diabetes and hyperlipidemia in folk medicine. The crude methanol extract and fractions of I. frutescens were investigated for antihyperlipidemic effect. Fresh leaves of I. frutescens were extracted with methanol and fractionated
Sadaf Matinkhoo et al.
Journal of pharmaceutical sciences, 100(12), 5197-5205 (2011-10-25)
Myoviridae bacteriophages were processed into a dry powder inhalable dosage form using a low-temperature spray-drying process. The phages were incorporated into microparticles consisting of trehalose, leucine, and optionally a third excipient (either a surfactant or casein sodium salt). The particles
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