Skip to Content
Merck
All Photos(3)

Documents

SRE0050

Sigma-Aldrich

Aprotinin

3-7 TIU/mg protein, saline solution, Suitable for manufacturing of diagnostic kits and reagents

Synonym(s):

Aprotinin from bovine lung, BPTI, Bovine pancreatic trypsin inhibitor, Trasylol, Trypsin inhibitor (basic)

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Empirical Formula (Hill Notation):
C284H432N84O79S7
CAS Number:
9087-70-1
Molecular Weight:
6511.44
MDL number:
MFCD00130541
UNSPSC Code:
12352200
NACRES:
NA.32

product name

Aprotinin from bovine lung, saline solution, 3-7 TIU/mg protein

description

For research or further manufacturing use only. Not intended for direct use in humans or animals. Non-TSCA use only in US.

Quality Level

400

form

saline solution

specific activity

3-7 TIU/mg protein

mol wt

~6,500

shipped in

wet ice

storage temp.

2-8°C

InChI key

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Aprotinin is largely used as an inhibitor of trypsin.

Biochem/physiol Actions

Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.

Unit Definition

One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Zhiwei Chen et al.
Oncogenesis, 9(5), 49-49 (2020-05-15)
Carbidopa, a peripheral decarboxylase inhibitor used with L-DOPA to treat Parkinson's disease, has attracted significant interest in recent years for its anticancer effect. Increasing evidence reveals that Carbidopa can inhibit cancer cell growth and induce apoptosis through aryl hydrocarbon receptor
Gen Chen et al.
Redox biology, 41, 101904-101904 (2021-03-12)
Protein S-nitrosylation is a reversible protein modification implicated in both physiological and pathophysiological regulation of protein function. However, the relationship between dysregulated S-nitrosylation homeostasis and diabetic vascular complications remains incompletely understood. Here, we demonstrate that basic fibroblast growth factor (bFGF)
Yingjie Shen et al.
International journal of molecular sciences, 22(10) (2021-06-03)
Prostate cancer (PCa) is the second most leading cause of death in males. Our previous studies have demonstrated that δ-catenin plays an important role in prostate cancer progression. However, the molecular mechanism underlying the regulation of δ-catenin has not been

Articles

Aprotinin Applications in Biotechnology and Pharmaceutical Manufacturing Processes

The Elevate Program offers enhanced quality and documentation attributes for aprotinin, a protease inhibitor used in multiple relevant industries.

Aprotinin Applications in Biotechnology and Pharmaceutical Manufacturing Processes

The Elevate Program offers enhanced quality and documentation attributes for aprotinin, a protease inhibitor used in multiple relevant industries.

Aprotinin Applications in Biotechnology and Pharmaceutical Manufacturing Processes

The Elevate Program offers enhanced quality and documentation attributes for aprotinin, a protease inhibitor used in multiple relevant industries.

Aprotinin Applications in Biotechnology and Pharmaceutical Manufacturing Processes

The Elevate Program offers enhanced quality and documentation attributes for aprotinin, a protease inhibitor used in multiple relevant industries.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service