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SML1370

Sigma-Aldrich

A-779 trifluoroacetate salt

≥98% (HPLC)

Synonym(s):

A779 trifluoroacetate salt, Asp1-Arg2-Val3-Tyr4-Ile5-His6-D-Ala7, D-Ala7-Ang-(1-7), DRVYIHA (Modification: Ala-7 = D-Ala), DRVYIHa trifluoroacetate salt, H-Asp-Arg-Val-Tyr-Ile-His-D-Ala-OH trifluoroacetate salt, [7-D-ALA]-angiotensin-(1-7) trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C39H60N12O11 · xC2HF3O2
CAS Number:
159432-28-7
Molecular Weight:
872.97 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

lyophilized powder

color

white to off-white

shipped in

wet ice

storage temp.

−20°C

Biochem/physiol Actions

A-779 (D-Ala7-Ang-(1-7)) is a potent and selective antagonist of angiotensin (1-7), an endogenous peptide that acts through activation of a non-AT1, non-AT2 receptor, Mas, and opposes the activity of angiotensin. A-779 has an IC50 of 0.3 nM for Mas with negligible affinity for either AT1R or AT2R.
A-779 is a potent and selective antagonist of angiotensin (1-7).
This blocking angiotensin action affects cardiovascular function.[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000163787
0000163787
0000159835
0000159835
0000130241

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Cardiovascular actions of angiotensin-(1-7)
Ferreira AJ and Santos RAS
Brazilian journal of medical and biological research, 38(4), 499-507 (2005)
Gustavo B Lamy et al.
Frontiers in physiology, 12, 682711-682711 (2021-07-30)
Central micturition control and urine storage involve a multisynaptic neuronal circuit for the efferent control of the urinary bladder. Electrical stimulation of the lateral preoptic area (LPA) at the level of the decussation of the anterior commissure in cats evokes

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