L1026

Lidocaine

analytical standard

• Synonym(s): 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine
• Empirical Formula (Hill Notation): C₁₄H₂₂N₂O
• CAS Number: 137-58-6
• Molecular Weight: 234.34
• EC Number: 205-302-8
• MDL number: MFCD00026733
• UNSPSC Code: 12352200
• PubChem Substance ID: 24896272
• NACRES: NA.77

Properties

• grade: analytical standard
• form: solid
• packaging: vial of 200 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• SMILES string: CCN(CC)CC(=O)Nc1c(C)cccc1C
• InChI: 1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
• InChI key: NNJVILVZKWQKPM-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Scnn1a(25122)

Description

General description

Lidocaine is an amide anesthetic, which is used to treat ventricular arrhythmias. It lowers cardiac automaticity and myocardial conduction. Lidocaine inhibits the generation and conduction of nerve impulses. It has an anticonvulsant effect.

Application

Lidocaine has been used to examine its effects in inhibiting lymph flow and protection against envenomation. It has also been used to assess its efficacy as an anti-tussive agent.

Biochem/physiol Actions

Na⁺ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.

Packaging

Supplied in amber screw-cap vials

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves