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C4284

Sigma-Aldrich

β-Chloro-D-alanine hydrochloride

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About This Item

Linear Formula:
C3H6NO2Cl · HCl
CAS Number:
Molecular Weight:
160.00
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32

Assay

≥98% (TLC)

form

powder

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

storage temp.

−20°C

SMILES string

Cl.N[C@H](CCl)C(O)=O

InChI

1S/C3H6ClNO2.ClH/c4-1-2(5)3(6)7;/h2H,1,5H2,(H,6,7);1H/t2-;/m1./s1

InChI key

IENJPSDBNBGIEL-HSHFZTNMSA-N

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J M Manning et al.
Proceedings of the National Academy of Sciences of the United States of America, 71(2), 417-421 (1974-02-01)
The D- and L-isomers of beta-chloroalanine inhibit the growth of Diplococcus pneumoniae, Streptococcus pyogenes, Bacillus subtilis, and Escherichia coli. With pneumococcus the inhibition by beta-chloro-D-alanine is completely prevented by either D-alanine or D-alanyl-D-alanine, while L-alanine is not effective in preventing
Babita S Gupta et al.
International journal of pharmaceutics, 238(1-2), 43-50 (2002-05-09)
The present study was designed to investigate the role of skin sphingosine synthesis inhibition in enhancing the in vitro permeation of levodopa (LD), a hydrophilic drug, across rat skin. beta-Chloroalanine (beta-CA), a selective inhibitor of serine palmitoyl transferase was used
Subramanian Karthikeyan et al.
Biochemistry, 43(42), 13328-13339 (2004-10-20)
1-Aminocyclopropane-1-carboxylate (ACC) deaminase is a pyridoxal 5'-phosphate (PLP) dependent enzyme catalyzing the opening of the cyclopropane ring of ACC to give alpha-ketobutyric acid and ammonia as the products. This ring cleavage reaction is unusual because the substrate, ACC, contains no
Yuki Ogasawara et al.
Journal of biochemical and biophysical methods, 51(2), 139-150 (2002-06-14)
A highly sensitive method has been developed for the determination of gamma-cystathionase (EC. 4.4.1.1.) activity in rat tissues using beta-chloro-L-alanine as a substrate. This method is based on colorimetry for the determination of pyruvate produced from beta-chloro-L-alanine with the beta-elimination
Geoffrey A Mueller et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 165(2), 237-247 (2003-12-04)
A new approach for the isotopic labeling of proteins is proposed that aims to facilitate side chain resonance assignments. Residue-correlated (RC) labeling is achieved by the expression of a protein on a medium containing a mixture of labeled, e.g., [U-13C,15N]amino

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