MAB1598
Anti-Post Synaptic Density Protein 95 Antibody, clone 7E3-1B8
clone 7E3-1B8, Chemicon®, from mouse
Synonym(s):
PSD-95
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
7E3-1B8, monoclonal
species reactivity
bovine, rat, mouse
species reactivity (predicted by homology)
human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
bovine ... Dlg4(100137840)
human ... DLG4(1742)
mouse ... Dlg4(13385)
rat ... Dlg4(29495)
General description
The postsynaptic density (PSD) is an electron dense structure just beneath the postsynaptic membrane. Several functions have been proposed for the PSD including regulating receptor number and clustering, anchoring signal transduction molecules at the synapse and mediating adhesion between the presynaptic and postsynaptic membranes. The most abundant PSD protein is the [alpha] subunit of the type II calcium/calmodulin dependent protein kinase ([alpha]CaMKII). This protein is likely to play a role in the calcium-mediated signal transduction at the synapse that mediates certain forms of synaptic plasticity. Another major PSD protein is PSD-95, a member of the guanylate kinase family (GUK) of proteins.
Specificity
Reacts with recombinant rat PSD-95 and identifies a band at approximately ~100 kDa, corresponding to PSD-95, on western blots of rat brain, mouse brain and bovine brain extracts. Also present in rat brain and mouse brain tissue extracts are bands of approximately 80 kDa and 50 kDa. PSD-95 is believed to initiate NMDA receptor clustering on the post synaptic membrane.
Immunogen
Recombinant rat PSD-95
Application
Anti-Post Synaptic Density Protein 95 Antibody, clone 7E3-1B8 is an antibody against Post Synaptic Density Protein 95 for use in IC, IP & WB.
Immunocytochemistry:
A previous lot of this antibody was used in IC.
Immunoprecipitation:
A previous lot of this antibody was used in IP.
Optimal working dilutions must be determined by the end user.
A previous lot of this antibody was used in IC.
Immunoprecipitation:
A previous lot of this antibody was used in IP.
Optimal working dilutions must be determined by the end user.
Quality
Evaluated by Western Blot on Mouse brain lysates.
Western Blot Analysis:
1:500 dilution of this antibody detected PSD-95 on 10 µg of Mouse brain lysates.
Western Blot Analysis:
1:500 dilution of this antibody detected PSD-95 on 10 µg of Mouse brain lysates.
Target description
~ 95 kDa
Linkage
Replaces: 04-1066
Physical form
Format: Purified
Purified mouse monoclonal IgG1 liquid in buffer containing PBS, pH 7.2, with 0.09% sodium azide and 50% glycerol.
Analysis Note
Control
Mouse brain, rat brain tissue
Mouse brain, rat brain tissue
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Description
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.
Zheng, S; Gray, EE; Chawla, G; Porse, BT; O'Dell, TJ; Black, DL
Nature Neuroscience null
Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease.
Lynch, G; Kramar, EA; Rex, CS; Jia, Y; Chappas, D; Gall, CM; Simmons, DA
The Journal of Neuroscience null
Activity-dependent local translation of matrix metalloproteinase-9.
Dziembowska, M; Milek, J; Janusz, A; Rejmak, E; Romanowska, E; Gorkiewicz, T; Tiron et al.
The Journal of Neuroscience null
Paul E Gottschall et al.
Experimental brain research, 201(4), 885-893 (2010-02-20)
The purpose of this study was to develop ELISAs for key neural proteins, three synaptic and one glial, that exist in different intracellular compartments, which would be used as a measure of synaptic phenotype. These assays would be valuable to
Rachel D Penrod et al.
Journal of neuroscience methods, 200(1), 1-13 (2011-06-16)
Dendritic spines of striatal Medium Spiny Neurons (MSNs) receive converging dopaminergic and glutamatergic inputs. These spines undergo experience-dependent structural plasticity following repeated drug administration and during disease states like Huntington's and Parkinson's. Thus, understanding the molecular mechanisms leading to structural
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