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Sigma-Aldrich

γ-Secretase Inhibitor I

The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

Synonym(s):

γ-Secretase Inhibitor I, Z-LLNle-CHO

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About This Item

Empirical Formula (Hill Notation):
C26H41N3O5
Molecular Weight:
475.62
UNSPSC Code:
12352200
NACRES:
NA.54

Quality Level

Assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

DMSO: 10 mg/mL
50% acetic acid: soluble

shipped in

ambient

storage temp.

−20°C

General description

Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease.
Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
γ-secretase
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Leu-Leu-Nle-CHO (Nle = Norleucine)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Skovronsky, D.M., et al. 2000. Biochemistry 39, 810.
Hartmann, T., et al. 1997. Nat. Med. 3, 1016.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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