850315C
Avanti
08:0 PC
1,2-dioctanoyl-sn-glycero-3-phosphocholine, chloroform
Synonym(s):
PC(8:0/8:0)
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About This Item
Empirical Formula (Hill Notation):
C24H48NO8P
CAS Number:
Molecular Weight:
509.61
UNSPSC Code:
51191904
NACRES:
NA.25
Assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 2.5 mL (850315C-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850315C
concentration
10 mg/mL (850315C-25mg)
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
General description
Phosphatidylcholine (PC), a major phospholipid is mostly found in the membrane of mammals. The headgroup of this bilayer-forming lipid carries a positively and negatively charged quaternary amine and a phosphate respectively. 08:0 PC (1,2-dioctanoyl-sn-glycero-3-phosphocholine) is a saturated synthetic short-chain phospholipid.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.
Application
08:0 PC (1,2-dioctanoyl-sn-glycero-3-phosphocholine) has been used to form a lipid film to study its effect on P-glycoprotein′s (P-gp′s) activity/to compare its effect with TWEEN®80 and Cremophor®EL. It may be used to study its effect on the nicotinamide adenine dinucleotide (NADH): n-decylubiquinone (DBQ) activity of complex I. It may also be used as a bicellar model to study their phase behavior.
Packaging
5 mL Clear Glass Sealed Ampule (850315C-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Cremophor is a registered trademark of BASF SE
TWEEN is a registered trademark of Croda International PLC
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
Target Organs
Central nervous system, Liver,Kidney
WGK
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Phase behavior of a binary lipid system containing long- and short-chain phosphatidylcholines
Sun HY, et al.
Royal Society of Chemistry Advances, 7(10), 5715-5724 null
Lipid-Protein Interactions in Membranes
The Membranes of Cells, 291-334 null
Manuel Weinheimer et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 108, 13-22 (2016-09-04)
The efflux transporter P-glycoprotein (P-gp) significantly modulates drug transport across the intestinal mucosa, strongly reducing the systemic absorption of various active pharmaceutical ingredients. P-gp inhibitors could serve as helpful tools to enhance the oral bioavailability of those substances. As a
Teruhiko Baba et al.
Chemistry and physics of lipids, 227, 104870-104870 (2020-01-10)
Interfacial properties and membrane protein solubilization activity of a series of partially fluorinated octyl-phosphocholine (PC) surfactants were investigated from the viewpoint of the fluorination degree of the hydrophobic chain. The critical micelle concentration (CMC), surface tension lowering activity, molecular occupied
Stefan Dröse et al.
Biochimica et biophysica acta, 1556(1), 65-72 (2002-09-28)
NADH:ubiquinone oxidoreductase (complex I) is the largest multiprotein complex of the mitochondrial respiratory chain. His-tagged complex I purified from the strictly aerobic yeast Yarrowia lipolytica exhibited electron transfer rates from NADH to n-decylubiquinone of less than 2% when compared to
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